RESUMO
Obesity is closely associated with increased incidence of cardiovascular diseases, cancer, insulin resistance, and immune dysfunction, and thus obesity-mitigation strategies should take into account these secondary pathologies in addition to promoting weight loss. Recent studies indicate that black cumin (Nigella sativa) has cardio-protective, anti-cancer, anti-diabetic, antioxidant, and immune-modulatory properties. While black cumin and/or its major bioactive constituent, thymoquinone have demonstrated bioactivity in a variety of disease models, the mechanisms of action are largely unknown. Given the growing interest in and the use of functional foods and nutraceuticals, as well as the increase in obesity and chronic diseases worldwide, further research into the therapeutic/preventive effects of black cumin may be beneficial.
Assuntos
Benzoquinonas/farmacologia , Nigella sativa/química , Obesidade/tratamento farmacológico , Extratos Vegetais/farmacologia , Antioxidantes/farmacologia , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/prevenção & controle , Quimiorradioterapia Adjuvante/métodos , Humanos , Resistência à Insulina , Neoplasias/complicações , Neoplasias/prevenção & controle , Nigella sativa/toxicidade , Obesidade/complicações , Redução de PesoRESUMO
Examination of the acetone extract of the aerial parts of Hypericum ellipticum afforded a new acetylated benzophenone glucoside (3'-O-beta-D-3",4",6"-triacetylglucopyranosyl-2,4,5',6-tetrahydroxybenzophenone) together with catechin and epicatechin. The structure of the benzophenone glucoside was determined by 2D NMR spectroscopic data. The compound inhibited the proliferation of CNS tumor cell line (SF-268) and lipid peroxidation in in vitro assays.