Detalhe da pesquisa
1.
Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations.
Eur Respir J
; 61(6)2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37105573
2.
Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.
J Enzyme Inhib Med Chem
; 38(1): 2242714, 2023 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37592917
3.
Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators.
J Enzyme Inhib Med Chem
; 38(1): 2157825, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36629421
4.
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies.
J Enzyme Inhib Med Chem
; 37(1): 299-314, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34894955
5.
Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies.
J Enzyme Inhib Med Chem
; 37(1): 1389-1403, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35577416
6.
New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies.
J Enzyme Inhib Med Chem
; 37(1): 397-410, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34961427
7.
Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation.
J Enzyme Inhib Med Chem
; 37(1): 2063-2077, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35875937
8.
Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies.
Molecules
; 27(19)2022 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36234734
9.
Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors.
Bioorg Med Chem
; 29: 115872, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214036
10.
Discovery of novel triazolophthalazine derivatives as DNA intercalators and topoisomerase II inhibitors.
Arch Pharm (Weinheim)
; 354(6): e2000456, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33554352
11.
Pyridine-derived VEGFR-2 inhibitors: Rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking.
Arch Pharm (Weinheim)
; 354(8): e2100085, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-33948983
12.
In Silico Exploration of Potential Natural Inhibitors against SARS-Cov-2 nsp10.
Molecules
; 26(20)2021 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34684735
13.
Discovery of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors: Design, synthesis, and anti-proliferative evaluation.
Bioorg Chem
; 105: 104380, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33128967
14.
Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors.
Bioorg Chem
; 103: 104233, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32882440
15.
Combined treatments with metformin and phosphodiesterase inhibitors alleviate nonalcoholic fatty liver disease in high-fat diet fed rats: a comparative study.
Can J Physiol Pharmacol
; 98(8): 498-505, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32083947
16.
Identification of Ureidocoumarin-Based Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors via Drug Repurposing Approach, Biological Evaluation, and In Silico Studies.
Pharmaceuticals (Basel)
; 17(4)2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38675389
17.
Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers.
RSC Adv
; 13(32): 22122-22147, 2023 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37492514
18.
Trimetazidine alleviates paclitaxel-induced peripheral neuropathy through modulation of TLR4/p38/NF-κB and klotho protein expression.
Chem Biol Interact
; 376: 110446, 2023 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36898573
19.
Protective effect of empagliflozin on gentamicin-induced acute renal injury via regulation of SIRT1/NF-κB signaling pathway.
Environ Toxicol Pharmacol
; 94: 103907, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35697188
20.
Mitochondrial Regulation of the Hypoxia-Inducible Factor in the Development of Pulmonary Hypertension.
J Clin Med
; 11(17)2022 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36079149