Detalhe da pesquisa
1.
Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO).
Bioorg Med Chem Lett
; 42: 128010, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811992
2.
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Bioorg Med Chem
; 28(22): 115723, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007547
3.
Pharmacological characterization of a novel liver X receptor agonist with partial LXRα activity and a favorable window in nonhuman primates.
J Pharmacol Exp Ther
; 352(2): 305-14, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25467132
4.
Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRß.
Bioorg Med Chem Lett
; 25(2): 372-7, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25435151
5.
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists.
ACS Med Chem Lett
; 13(6): 943-948, 2022 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35707160
6.
Molecular Mechanisms of Desensitization Underlying the Differential Effects of Formyl Peptide Receptor 2 Agonists on Cardiac Structure-Function Post Myocardial Infarction.
ACS Pharmacol Transl Sci
; 5(10): 892-906, 2022 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36268126
7.
Plasma biomarkers associated with adverse outcomes in patients with calcific aortic stenosis.
Eur J Heart Fail
; 23(12): 2021-2032, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34632675
8.
Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.
JACC Basic Transl Sci
; 6(8): 676-689, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34466754
9.
Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure.
J Med Chem
; 63(17): 9003-9019, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32407089
10.
Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment.
JACC Basic Transl Sci
; 4(8): 905-920, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31909300
11.
Potent Triazolopyridine Myeloperoxidase Inhibitors.
ACS Med Chem Lett
; 9(12): 1175-1180, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613322
12.
Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.
Medchemcomm
; 8(11): 2093-2099, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108726
13.
Discovery of Highly Potent Liver X Receptor ß Agonists.
ACS Med Chem Lett
; 7(12): 1207-1212, 2016 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994765
14.
Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils.
Cell Metab
; 24(2): 223-33, 2016 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27508871
15.
Identification of novel functional inhibitors of 17beta-hydroxysteroid dehydrogenase type III (17beta-HSD3).
Prostate
; 65(2): 159-70, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15924334