Detalhe da pesquisa
1.
Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform.
Genes Chromosomes Cancer
; 58(6): 341-356, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30474255
2.
Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways.
Biogerontology
; 20(3): 337-358, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31041622
3.
Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.
Biogerontology
; 19(6): 579-602, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29907918
4.
The non-random repositioning of whole chromosomes and individual gene loci in interphase nuclei and its relevance in disease, infection, aging, and cancer.
Adv Exp Med Biol
; 773: 263-79, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24563352
5.
Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells.
Front Cell Dev Biol
; 9: 640200, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34113611
6.
Progeria, the nucleolus and farnesyltransferase inhibitors.
Biochem Soc Trans
; 38(Pt 1): 287-91, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20074076
7.
Towards a Drosophila model of Hutchinson-Gilford progeria syndrome.
Biochem Soc Trans
; 36(Pt 6): 1389-92, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19021561
8.
Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?
Biochem Soc Trans
; 36(Pt 6): 1384-8, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19021560
9.
Primary laminopathy fibroblasts display altered genome organization and apoptosis.
Aging Cell
; 6(2): 139-53, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17274801
10.
The nuclear lamina. Both a structural framework and a platform for genome organization.
FEBS J
; 274(6): 1354-61, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17489093
11.
Alterations to nuclear architecture and genome behavior in senescent cells.
Ann N Y Acad Sci
; 1100: 250-63, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17460187
12.
Heterogeneity of dimer excision in young and senescent human dermal fibroblasts.
Aging Cell
; 4(5): 247-55, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16164424
13.
Analysis of UV-induced damage and repair in young and senescent human dermal fibroblasts using the comet assay.
Mech Ageing Dev
; 126(6-7): 664-72, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15888320
14.
Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production.
Nucleus
; 6(6): 490-506, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652669
15.
Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis.
Exp Gerontol
; 39(5): 717-24, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15130666
16.
A structured environment helps to regulate nuclear architecture in breast epithelial cells.
Cell Cycle
; 15(9): 1178-9, 2016 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27078818
17.
Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells.
Genome Biol
; 12(8): R74, 2011 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21838864
18.
Progeria Research Day at Brunel University.
Nucleus
; 2(6): 517-22, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22064469
19.
The in vitro kinetics of senescence of Fischer 344 rat embryo fibroblasts.
Biogerontology
; 10(3): 285-9, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19115081
20.
A p53-independent pathway regulates nucleolar segregation and antigen translocation in response to DNA damage induced by UV irradiation.
Exp Cell Res
; 292(1): 179-86, 2004 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14720517