Detalhe da pesquisa
1.
A phase 2a, randomized, double-blind, placebo-controlled, three-arm, parallel-group study to assess the efficacy, safety, tolerability and pharmacodynamics of PF-06835919 in patients with non-alcoholic fatty liver disease and type 2 diabetes.
Diabetes Obes Metab
; 25(4): 992-1001, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36515213
2.
Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab.
N Engl J Med
; 376(16): 1517-1526, 2017 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28304227
3.
Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates.
Diabetes Obes Metab
; 19(12): 1762-1772, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28573777
4.
Diagnosis and ablation of multiform fascicular tachycardia.
J Cardiovasc Electrophysiol
; 24(3): 297-304, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23110306
5.
Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial.
Nat Med
; 27(6): 1079-1087, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34127852
6.
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
Nat Med
; 27(10): 1836-1848, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34635855
7.
Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization.
Circulation
; 120(7): 553-9, 2009 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19652097
8.
Arrhythmogenesis by single ectopic beats originating in the Purkinje system.
Am J Physiol Heart Circ Physiol
; 299(4): H1002-11, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20622103
9.
Prospective observations in the clinical and electrophysiological characteristics of intra-isthmus reentry.
J Cardiovasc Electrophysiol
; 21(10): 1099-106, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20455984
10.
Remote navigation guided ablation of incessant atrial tachycardia in a patient with restricted venous access.
J Cardiovasc Electrophysiol
; 20(9): 1061-4, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19207779
11.
Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis.
Sci Transl Med
; 11(520)2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31776293
12.
Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition.
PLoS One
; 14(3): e0214150, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30889221
13.
Impact of remote magnetic catheter navigation on ablation fluoroscopy and procedure time.
Pacing Clin Electrophysiol
; 31(11): 1399-404, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18950296
14.
Pharmacokinetics, pharmacodynamics, and safety of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, in healthy subjects when administered in co-mixture with recombinant human hyaluronidase: A phase 1 randomized trial.
Health Sci Rep
; 1(9): e61, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30623096
15.
New strategies for the development of lipid-lowering therapies to reduce cardiovascular risk.
Eur Heart J Cardiovasc Pharmacother
; 4(2): 119-127, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29194462
16.
New medicinal products for chronic heart failure: advances in clinical trial design and efficacy assessment.
Eur J Heart Fail
; 19(6): 718-727, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28345190
17.
Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency.
Eur J Heart Fail
; 18(5): 482-9, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27071916
18.
Pseudoventricular fibrillation.
J Electrocardiol
; 41(3): 229, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18444274
20.
Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation.
Front Pharmacol
; 3: 6, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22303294