Detalhe da pesquisa
1.
A new Caenorhabditis elegans model to study copper toxicity in Wilson disease.
Traffic
; 25(1): e12920, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37886910
2.
Elesclomol restores mitochondrial function in genetic models of copper deficiency.
Proc Natl Acad Sci U S A
; 115(32): 8161-8166, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30038027
3.
An extracellular histidine-containing motif in the zinc transporter ZIP4 plays a role in zinc sensing and zinc-induced endocytosis in mammalian cells.
J Biol Chem
; 294(8): 2815-2826, 2019 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30593504
4.
CHCA-1 is a copper-regulated CTR1 homolog required for normal development, copper accumulation, and copper-sensing behavior in Caenorhabditis elegans.
J Biol Chem
; 293(28): 10911-10925, 2018 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29784876
5.
The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.
Hum Mol Genet
; 26(23): 4617-4628, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28973536
6.
The Function of ATPase Copper Transporter ATP7B in Intestine.
Gastroenterology
; 154(1): 168-180.e5, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28958857
7.
The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans.
J Biol Chem
; 292(1): 1-14, 2017 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27881675
8.
Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
Proc Natl Acad Sci U S A
; 110(46): E4279-88, 2013 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24167251
9.
Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models.
J Clin Invest
; 133(1)2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36301669
10.
Oral Elesclomol Treatment Alleviates Copper Deficiency in Animal Models.
Front Cell Dev Biol
; 10: 856300, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35433682
11.
Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function.
Cell Metab
; 4(3): 235-44, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16950140
12.
Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability.
J Biol Chem
; 285(42): 32385-92, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20699218
13.
Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson's disease.
Eur J Med Chem
; 212: 113103, 2021 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33387904
14.
Mechanisms for copper acquisition, distribution and regulation.
Nat Chem Biol
; 4(3): 176-85, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18277979
15.
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice.
Science
; 368(6491): 620-625, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32381719
16.
Phenotypic diversity of Menkes disease in mottled mice is associated with defects in localisation and trafficking of the ATP7A protein.
J Med Genet
; 44(10): 641-6, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17483305
17.
Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis.
Sci Rep
; 7(1): 12001, 2017 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28931909
18.
A novel role for copper in Ras/mitogen-activated protein kinase signaling.
Mol Cell Biol
; 32(7): 1284-95, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22290441
19.
Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.
Cell Metab
; 11(5): 353-63, 2010 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20444417
20.
A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity.
J Biol Chem
; 282(10): 6992-7000, 2007 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17202136