Survey of canine use and safety of isoxazoline parasiticides.

A veterinarian and pet owner survey (Project Jake) examined the use and safety of isoxazoline parasiticides given to dogs. Data were received during August 1-31, 2018 from a total of 2,751 survey responses. Forty-two percent (1,157) reported no flea treatment or adverse events (AE), while 58% (1594) had been treated with some parasiticide for flea control, and of those that received a parasiticide, the majority, or 83% (1,325), received an isooxazoline. When any flea treatment was given, AE were reported for 66.6% of respondents, with no apparent AE noted for 36.1%. Project Jake findings were compared to a retrospective analysis of publicly available Food and Drug Administration (FDA) and European Medicines Agency (EMA) reported AE. The number of total AE reported to FDA and EMA were comparable, although a 7 to 10 times higher occurrence of death and seizures was reported from the EMA or from outside the United States (US). Serious AE responses for death, seizures and neurological effects reported in our survey were higher than the FDA but moderately lower than the EMA reports. These sizable global data sets combined with this pre- and post-parasiticide administration survey indicated that isoxazoline neurotoxicity was not flea- and tick-specific. Post-marketing serious AE were much higher than in Investigational New Drug (IND) submissions. Although the labels have recently been updated, dogs, cats and their caregivers remain impacted by their use. These aggregate data reports support the need for continued cross-species studies and critical review of product labelling by regulatory agencies and manufacturers.

Intraosseous blood supply to the distal humerus.

PURPOSE: Nonunion of the distal humerus after fracture or osteotomy is uncommon but can present an important clinical problem. Vascular insufficiency of bone may be an important contributing factor. The purpose of this study was to describe the intraosseous vascular anatomy of the distal humerus. METHODS: Nine fresh-frozen upper extremity cadaver specimens were injected with India ink and Ward's blue latex solution. A modified Spalteholz technique was used to show the intraosseous vascular anatomy. RESULTS: The distal humeral diaphysis was supplied by a single nutrient artery. The lateral column was supplied predominately by posterior segmental vessels, whereas the medial column was supplied by anterior and posterior segmental vessels. The trochlea, olecranon fossa, and coronoid fossa were watershed areas. CONCLUSIONS: Our study shows the intraosseous vascular anatomy of the distal humerus is relatively consistent. There also appears to be a consistent trochlear vessel medially and small anterior perforating vessels in the lateral column that have not previously been described.