Detalhe da pesquisa
1.
Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
J Med Chem
; 63(20): 11882-11901, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32914979
2.
A 14-day repeat dose oral gavage range-finding study of a first-in-class CDI investigational antibiotic, in rats.
Sci Rep
; 9(1): 158, 2019 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655592
3.
Biomarkers for nonclinical infusion reactions in marketed biotherapeutics and considerations for study design.
Curr Opin Toxicol
; 4: 1-15, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29658009
4.
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914).
J Med Chem
; 58(15): 6264-82, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26158756
5.
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Sci Rep
; 5: 11827, 2015 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26168713
6.
Corrigendum: Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Sci Rep
; 5: 14157, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26383116
7.
Hydroperoxy-10,12-octadecadienoic acid stimulates cytochrome P450 3A protein aggregation by a mechanism that is inhibited by substrate.
Biochemistry
; 42(43): 12691-9, 2003 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-14580217
8.
Prevalent overexpression of prolyl isomerase Pin1 in human cancers.
Am J Pathol
; 164(5): 1727-37, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15111319