RESUMO
Brevibacteria are a part of the normal skin flora and may be dismissed in blood cultures as contaminants. They have been reported as opportunistic pathogens in immunocompromised patients. We report a catheter-related bloodstream infection with Brevibacterium casei in a 6-year-old child with aplastic anaemia. Treatment with appropriate antibiotics along with the removal of the catheter resulted in complete cure in our patient.
Assuntos
Anemia Aplástica/complicações , Bacteriemia/complicações , Brevibacterium/isolamento & purificação , Infecções Relacionadas a Cateter/complicações , Infecções por Bactérias Gram-Positivas/complicações , Antibacterianos/uso terapêutico , Bacteriemia/microbiologia , Infecções Relacionadas a Cateter/tratamento farmacológico , Infecções Relacionadas a Cateter/microbiologia , Cateteres de Demora , Criança , Infecções por Bactérias Gram-Positivas/tratamento farmacológico , Infecções por Bactérias Gram-Positivas/microbiologia , Humanos , Hospedeiro Imunocomprometido , MasculinoRESUMO
The diagnosis of blood-borne infections in immunocompromised patients is a major challenge for the clinical microbiology laboratory. Isolation of bloodborne pathogens in these patients has profound clinical implications, yet is fraught with technical problems, including the presence of unusual and difficult to isolate pathogens. Coupled with this is the problem of false-positive blood culture signals from automated blood culture systems which further delays the definitive diagnosis. Here, we present a case of an 8-year-old boy with Ph +ve acute lymphoblastic leukaemia who has repeated 'false positive' blood cultures and later grew an uncommon organism.
Assuntos
Hemocultura/normas , Infecções Transmitidas por Sangue/diagnóstico , Infecções por Mycobacterium não Tuberculosas/diagnóstico , Mycobacterium abscessus/isolamento & purificação , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Amicacina/uso terapêutico , Antibacterianos/uso terapêutico , Azitromicina/uso terapêutico , Infecções Transmitidas por Sangue/sangue , Criança , Clofazimina/uso terapêutico , Diagnóstico Diferencial , Reações Falso-Positivas , Humanos , Hospedeiro Imunocomprometido , Levofloxacino/uso terapêutico , Masculino , Infecções por Mycobacterium não Tuberculosas/tratamento farmacológico , Mycobacterium abscessus/efeitos dos fármacos , Leucemia-Linfoma Linfoblástico de Células Precursoras/sangueRESUMO
Isolated cases of septicemia associated with probiotics have been reported. We describe Bacillus clausii septicemia in a 4-month-old male infant with congenital heart disease following treatment for diarrhea with a probiotic containing B. clausii spores. The septicemia proved refractory to treatment with antibiotics active against the pathogen and progressed to multidrug-resistant sepsis with multiorgan failure.