Detalhe da pesquisa
1.
Molecular Mechanism of Labelling Functional Cysteines by Heterocyclic Thiones.
Chemphyschem
; 25(1): e202300596, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37888491
2.
Tunable Heteroaromatic Nitriles for Selective Bioorthogonal Click Reaction with Cysteine.
Bioconjug Chem
; 34(7): 1271-1281, 2023 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37354098
3.
Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy.
Cell Mol Life Sci
; 79(1): 34, 2022 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34989869
4.
ProBiS-Dock: A Hybrid Multitemplate Homology Flexible Docking Algorithm Enabled by Protein Binding Site Comparison.
J Chem Inf Model
; 62(6): 1573-1584, 2022 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35289616
5.
Indoles and 1-(3-(benzyloxy)benzyl)piperazines: Reversible and selective monoamine oxidase B inhibitors identified by screening an in-house compound library.
Bioorg Chem
; 119: 105581, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34990933
6.
Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors.
Int J Mol Sci
; 23(3)2022 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35163706
7.
Screening of Big Pharma's Library against Various in-house Biological Targets.
Molecules
; 27(14)2022 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35889355
8.
N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases.
Molecules
; 27(21)2022 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36364263
9.
Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments.
Chembiochem
; 22(4): 743-753, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33030752
10.
Mur ligases inhibitors with azastilbene scaffold: Expanding the structure-activity relationship.
Bioorg Med Chem Lett
; 40: 127966, 2021 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744441
11.
WIDOCK: a reactive docking protocol for virtual screening of covalent inhibitors.
J Comput Aided Mol Des
; 35(2): 223-244, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33458809
12.
4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B.
Molecules
; 26(14)2021 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34299393
13.
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes.
J Enzyme Inhib Med Chem
; 35(1): 498-505, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31914836
14.
Cathepsin B inhibitors: Further exploration of the nitroxoline core.
Bioorg Med Chem Lett
; 28(7): 1239-1247, 2018 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29503024
15.
Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.
Molecules
; 23(2)2018 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29414887
16.
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
Bioorg Med Chem
; 25(2): 633-645, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27908752
17.
Synthesis and preliminary biological evaluations of (+)-isocampholenic acid-derived amides.
Mol Divers
; 20(3): 667-76, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27017352
18.
Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta.
Molecules
; 21(4): 410, 2016 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27023510
19.
Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.
Molecules
; 21(5)2016 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27187348
20.
Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (ß5 i) Subunit of the Immunoproteasome.
Angew Chem Int Ed Engl
; 55(19): 5745-8, 2016 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27037901