Detalhe da pesquisa
1.
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.
Cereb Cortex
; 31(2): 1395-1408, 2021 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33068001
2.
Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation.
Int J Neuropsychopharmacol
; 24(6): 505-518, 2021 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33438026
3.
The Effects of pH on the Structure and Bioavailability of Imidazobenzodiazepine-3-Carboxylate MIDD0301.
Mol Pharm
; 17(4): 1182-1192, 2020 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32069056
4.
Cerebellar α6GABAA Receptors as a Therapeutic Target for Essential Tremor: Proof-of-Concept Study with Ethanol and Pyrazoloquinolinones.
Neurotherapeutics
; 20(2): 399-418, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36696034
5.
High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand formulated in lipid nanoparticles: Physicochemical, structural and pharmacokinetic performances.
Int J Pharm
; 633: 122613, 2023 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36657554
6.
Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study.
Eur J Pharm Sci
; 189: 106557, 2023 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37544333
7.
Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus.
Behav Brain Res
; 416: 113578, 2022 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34508769
8.
The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders.
Pharmacol Biochem Behav
; 213: 173321, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041859
9.
Targeting α6GABAA receptors as a novel therapy for schizophrenia: A proof-of-concept preclinical study using various animal models.
Biomed Pharmacother
; 150: 113022, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35483195
10.
α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia.
Neurotherapeutics
; 18(1): 569-585, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33111258
11.
The α6 GABAA Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome.
Biomolecules
; 11(2)2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33525455
12.
Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABAA receptor subtypes.
Drug Alcohol Depend
; 228: 108985, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500240
13.
Identification and Quantification of MIDD0301 Metabolites.
Curr Drug Metab
; 22(14): 1114-1123, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34856893
14.
Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach.
Pharmaceutics
; 13(8)2021 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34452149
15.
Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301.
Org Process Res Dev
; 24(8): 1467-1476, 2020 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32952391
16.
Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models.
ACS Pharmacol Transl Sci
; 3(6): 1381-1390, 2020 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33344908
17.
Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance.
Eur J Pharm Sci
; 152: 105432, 2020 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32565331
18.
Design, synthesis and characterization of novel gammaaminobutyric acid type A receptor ligands.
ARKIVOC
; 2020(Pt 7): 242-256, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33642954
19.
Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects.
ACS Chem Neurosci
; 11(17): 2624-2637, 2020 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786313
20.
Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABAA receptors.
Eur J Pain
; 23(5): 973-984, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30633839