Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
Mais filtros

Base de dados
Tipo de documento
Intervalo de ano de publicação
1.
Eur Neurol ; 80(5-6): 335-340, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30928974

RESUMO

OBJECTIVES: The motor symptoms of Parkinson's disease (PD) vary among patients and have been categorized into 3 subtypes: tremor dominant, akinetic rigidity, and postural instability and gait disturbance (PIGD). Cerebral microbleed (CMB) is prevalent in people with PD and is associated with some nonmotor symptoms. The present study investigated the association between CMB and the motor subtypes of PD. MATERIALS AND METHODS: From 2009 to 2017, medical records and brain magnetic resonance imaging (MRI) reports of 134 Taiwanese people with early- and mid-stage PD were reviewed. CMBs were quantified according to the Microbleed Anatomical Rating Scale through susceptibility-weighted MRI. Motor subtypes were determined by medical chart review. Student's t test and multivariable logistic regression were used to analyze the association between the motor subtypes and CMB. Statistical analyses were performed using SPSS 19.0. RESULTS: Overall, 72 (53.7%) participants were women with a mean age of 69.5 ± 9.8 years. The prevalence of CMB was 33.6%, and lobar, deep, and infratentorial CMBs comprised 21.6, 19.4, and 11.9% of cases, respectively. PIGD subtype PD was associated with a significantly higher prevalence of any CMB as well as deep or lobar CMB. After adjustment for age and sex, the PIGD subtype was significantly positively associated with the presence of any, deep, and white matter (WM) and thalamic CMB. CONCLUSIONS: CMB was prevalent in Taiwanese people with early- and mid-stage PD, especially the PIGD subtype. Deep, especially thalamic and WM, CMBs exhibited the highest association with the PIGD subtype.


Assuntos
Hemorragia Cerebral/complicações , Doença de Parkinson/complicações , Idoso , Hemorragia Cerebral/epidemiologia , Feminino , Transtornos Neurológicos da Marcha/etiologia , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Equilíbrio Postural/fisiologia , Prevalência
2.
Parkinsonism Relat Disord ; 111: 105431, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-37164870

RESUMO

Magnetic resonance-guided focused ultrasound (MRgFUS) is a new surgical treatment for Parkinson's disease (PD). Previous experience with radiofrequency lesionectomy and deep brain stimulation (DBS) has identified several candidate targets for MRgFUS intended to alleviate the motor symptoms of PD. The main advantage of MRgFUS is that it is incisionless. MRgFUS has certain limitations and is associated with adverse effects. The present study reviews the literature on conventional surgical interventions for PD, discusses recent studies on MRgFUS, and the comparison between DBS and MRgFUS for PD. The reviews aims to provide an essential reference for neurologists to select the appropriate treatments for patients with PD.


Assuntos
Estimulação Encefálica Profunda , Tremor Essencial , Doença de Parkinson , Procedimentos Cirúrgicos Ultrassônicos , Humanos , Doença de Parkinson/diagnóstico por imagem , Doença de Parkinson/cirurgia , Resultado do Tratamento , Tremor Essencial/terapia , Imageamento por Ressonância Magnética , Espectroscopia de Ressonância Magnética
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA