Detalhe da pesquisa
1.
Discovery of benzo[f]pyrido[4,3-b][1,4]oxazepin-10-one derivatives as orally available bromodomain and extra-terminal domain (BET) inhibitors with efficacy in an in vivo psoriatic animal model.
Bioorg Med Chem
; 34: 116015, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33549905
2.
Autofluorescence changes of tomato surface tissues during overripening.
Photochem Photobiol Sci
; 19(7): 879-884, 2020 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32579662
3.
Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.
Bioorg Med Chem Lett
; 27(4): 1045-1049, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28082037
4.
Discovery of novel pyrazolo[1,5-a]pyridine-based EP1 receptor antagonists by scaffold hopping: Design, synthesis, and structure-activity relationships.
Bioorg Med Chem Lett
; 27(17): 4044-4050, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28784294
5.
Novel pyrazolo[1,5-a]pyridines as orally active EP1 receptor antagonists: Synthesis, structure-activity relationship studies, and biological evaluation.
Bioorg Med Chem
; 25(9): 2635-2642, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28342692
6.
Identification of novel 1,2,3,6-tetrahydropyridyl-substituted benzo[d]thiazoles: Lead generation and optimization toward potent and orally active EP1 receptor antagonists.
Bioorg Med Chem
; 25(13): 3406-3430, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28483455
7.
Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction.
Mol Pharmacol
; 89(1): 176-86, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26494861
8.
Phosphodiesterase inhibitors. Part 6: design, synthesis, and structure-activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity.
Bioorg Med Chem Lett
; 23(19): 5311-6, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23988356
9.
Phosphodiesterase inhibitors. Part 5: hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration.
Bioorg Med Chem Lett
; 23(1): 375-81, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200255
10.
Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA2.
Bioorg Med Chem Lett
; 23(5): 1553-6, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23333209
11.
Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2).
Bioorg Med Chem Lett
; 22(2): 868-71, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22217870
12.
6-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3ß: discovery of nitrile derivatives with picomolar potency.
Bioorg Med Chem Lett
; 22(2): 1005-8, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22202172
13.
Phosphodiesterase inhibitors. Part 4: design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones.
Bioorg Med Chem Lett
; 22(18): 5833-8, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22884989
14.
Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3ß (GSK-3ß) inhibitors for type 2 diabetics.
Bioorg Med Chem
; 20(3): 1188-200, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22261023
15.
Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity.
Bioorg Med Chem
; 20(5): 1644-58, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22336247
16.
An improved method for synthesis of 4,4-dimethylpyrazolone and application to dihydropyridazinone ring formation.
Chem Pharm Bull (Tokyo)
; 60(2): 267-9, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22293489
17.
Phosphodiesterase inhibitors. Part 2: design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity.
Bioorg Med Chem Lett
; 21(18): 5451-6, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21764304
18.
Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast.
Bioorg Med Chem Lett
; 21(11): 3307-12, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21530250
19.
Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3ß.
Bioorg Med Chem Lett
; 21(19): 5948-51, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21873061
20.
Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure.
J Med Chem
; 63(17): 9003-9019, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32407089