Detalhe da pesquisa
1.
The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.
Nature
; 610(7932): 547-554, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36198790
2.
Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Nature
; 595(7867): 404-408, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34163073
3.
Molecular basis for antibody recognition of multiple drug-peptide/MHC complexes.
Proc Natl Acad Sci U S A
; 121(22): e2319029121, 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38781214
4.
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
Cell
; 147(2): 306-19, 2011 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22000011
5.
Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Proc Natl Acad Sci U S A
; 120(28): e2302485120, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37399416
6.
Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket.
Proc Natl Acad Sci U S A
; 119(43): e2204481119, 2022 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36252024
7.
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nat Chem Biol
; 18(7): 706-712, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35361990
8.
Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT.
Nature
; 553(7689): 526-529, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29342140
9.
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies.
Proc Natl Acad Sci U S A
; 117(15): 8468-8475, 2020 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32234780
10.
Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.
Mol Cell
; 54(6): 1034-1041, 2014 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24910098
11.
Allosteric modulation of a human protein kinase with monobodies.
Proc Natl Acad Sci U S A
; 116(28): 13937-13942, 2019 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31239342
12.
Crystal structures of a double-barrelled fluoride ion channel.
Nature
; 525(7570): 548-51, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26344196
13.
Facile target validation in an animal model with intracellularly expressed monobodies.
Nat Chem Biol
; 14(9): 895-900, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30013062
14.
Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region.
Proc Natl Acad Sci U S A
; 114(38): 10095-10100, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28874577
15.
Inhibition of RAS function through targeting an allosteric regulatory site.
Nat Chem Biol
; 13(1): 62-68, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27820802
16.
Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Nature
; 497(7447): 137-41, 2013 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23604254
17.
sNASP and ASF1A function through both competitive and compatible modes of histone binding.
Nucleic Acids Res
; 45(2): 643-656, 2017 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28123037
18.
Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation.
Proc Natl Acad Sci U S A
; 113(8): 2092-7, 2016 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26862167
19.
Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface.
J Biol Chem
; 291(16): 8836-47, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26912659
20.
Monobody-mediated alteration of enzyme specificity.
Nat Chem Biol
; 11(10): 762-4, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26322825