Impact of Health Education in Combination with Nutrition Support Nursing on the Nutritional Status and Quality of Life in Patients with Pulmonary Tuberculosis.

This study aimed to ascertain the effects of health education combined with nutrition support nursing on the nutritional status and quality of life of patients with pulmonary tuberculosis. A clinical study was conducted. Sixty-four patients with tuberculosis were selected as the study participants and divided into control and observation groups (n = 32). Both groups received antituberculosis drugs. The control group received standard nursing care, while the observation group received health education in conjunction with nutrition support nursing. After 3 months of intervention, the total effective treatment rate and adherence were compared. Before and after the intervention, the albumin (ALB), prealbumin (PA), transferrin (TF), and hemoglobin (Hb) level, body mass index (BMI), and Short Form-36 (SF-36) scores were compared. The occurrence of adverse reactions during intervention was recorded. Following the intervention, the observation group exhibited a higher treatment total effective rate and increased levels of ALB, PA, TF, Hb, and BMI compared with the control group (p < 0.05). The observation group demonstrated a higher total adherence rate and a lower incidence of adverse reactions compared with the control group (p < 0.05); the SF-36 score of the observation group was higher than that of the control group (p < 0.05). The integration of health education and nutrition support nursing can effectively enhance the therapeutic outcomes of patients with pulmonary tuberculosis. This approach not only improves their nutritional status, treatment adherence, and quality of life, but also reduces the incidence of adverse reactions. The findings of this study lay a solid foundation for further exploration of the combined effects of health education and nutrition support nursing on pulmonary tuberculosis.

Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.

BACKGROUND: The astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity in brain region-specific pattern. Functional alterations of reactive astrocytes are commonly present in human temporal lobe epilepsy (TLE) cases, meanwhile the neuroinflammation mediated by reactive astrocytes may advance the development of hippocampal epilepsy in animal models. Nuclear factor I-A (NFIA) may regulate astrocyte diversity in the adult brain. However, whether NFIA endows the astrocytes with regional specificity to be involved in epileptogenesis remains elusive. METHODS: Here, we utilize an interference RNA targeting NFIA to explore the characteristics of NFIA expression and its role in astrocyte reactivity in a 4-aminopyridine (4-AP)-induced seizure model in vivo and in vitro. Combined with the employment of a HA-tagged plasmid overexpressing NFIA, we further investigate the precise mechanisms how NIFA facilitates epileptogenesis. RESULTS: 4-AP-induced NFIA upregulation in hippocampal region is astrocyte-specific, and primarily promotes detrimental actions of reactive astrocyte. In line with this phenomenon, both NFIA and vanilloid transient receptor potential 4 (TRPV4) are upregulated in hippocampal astrocytes in human samples from the TLE surgical patients and mouse samples with intraperitoneal 4-AP. NFIA directly regulates mouse astrocytic TRPV4 expression while the quantity and the functional activity of TRPV4 are required for 4-AP-induced astrocyte reactivity and release of proinflammatory cytokines in the charge of NFIA upregulation. NFIA deficiency efficiently inhibits 4-AP-induced TRPV4 upregulation, weakens astrocytic calcium activity and specific astrocyte reactivity, thereby mitigating aberrant neuronal discharges and neuronal damage, and suppressing epileptic seizure. CONCLUSIONS: Our results uncover the critical role of NFIA in astrocyte reactivity and illustrate how epileptogenic brain injury initiates cell-specific signaling pathway to dictate the astrocyte responses.

Anchoring Polar Organic Molecules in Defective Ammonium Vanadate for High-Performance Flexible Aqueous Zinc-Ion Battery.

Ammonium vanadate (NVO) often has unsatisfactory electrochemical performance due to the irreversible removal of NH4 + during the reaction. Herein, layered DMF-NVO nanoflake arrays (NFAs) grown on highly conductive carbon cloth (CC) are employed as the binder-free cathode (DMF-NVO NFAs/CC), which produces an enlarged interlayer spacing of 12.6 Å (against 9.5 Å for NH4 V4 O10 ) by effective N, N-dimethylformamide (DMF) intercalation. Furthermore, the strong attraction of highly polar carbonyl and ammonium ions in DMF can stabilize the lattice structure, and low-polar alkyl groups can interact with the weak electrostatic generated by Zn2+ , which allows Zn2+ to be freely intercalated. The DMF-NVO NFAs/CC//Zn battery exhibits an impressive high capacity of 536 mAh g-1 at 0.5 A g-1 , excellent rate capability, and cycling performance. The results of density functional theory simulation demonstrate that the intercalation of DMF can significantly reduce the band gap and the diffusion barrier of Zn2+ , and can also accommodate more Zn2+ . The assembled flexible aqueous rechargeable zinc ion batteries (FARZIBs) exhibit outstanding energy density and power density, up to 436 Wh kg-1 at 400 W kg-1 , and still remains 180 Wh kg-1 at 4000 W kg-1 . This work can provide a reference for the design of cathode materials for high-performance FARZIBs.

Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy.

Epilepsy is a common brain disorder, repeated seizures of epilepsy may lead to a series of brain pathological changes such as neuronal or glial damage. However, whether circular RNAs are involved in neuronal injury during epilepsy is not fully understood. Here, we screened circIgf1r in the status epilepticus model through circRNA sequencing, and found that it was upregulated after the status epilepticus model through QPCR analysis. Astrocytes polarizing toward neurotoxic A1 phenotype and neurons loss were observed after status epilepticus. Through injecting circIgf1r siRNA into the lateral ventricle, it was found that knocking down circIgf1r in vivo would induce the polarization of astrocytes to phenotype A2 and reduce neuronal loss. The results in vitro further confirmed that inhibiting the expression of circIgf1r in astrocytes could protect neurons by converting reactive astrocytes from A1 to the protective A2. In addition, knocking down circIgf1r in astrocytes could functionally promote astrocyte autophagy and relieve the destruction of 4-AP-induced autophagy flux. In terms of mechanism, circIgf1r promoted the polarization of astrocytes to phenotype A1 by inhibiting autophagy. Taken together, our results reveal circIgf1r may serve as a potential target for the prevention and treatment of neuron damage after epilepsy.

TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain.

BACKGROUND: Neonatal hypoxic-ischemic brain damage (HIBD), a leading cause of neonatal mortality, has intractable sequela such as epilepsy that seriously affected the life quality of HIBD survivors. We have previously shown that ion channel dysfunction in the central nervous system played an important role in the process of HIBD-induced epilepsy. Therefore, we continued to validate the underlying mechanisms of TRPV1 as a potential target for epilepsy. METHODS: Neonatal hypoxic ischemia and oxygen-glucose deprivation (OGD) were used to simulate HIBD in vivo and in vitro. Primarily cultured astrocytes were used to assess the expression of TRPV1, glial fibrillary acidic protein (GFAP), cytoskeletal rearrangement, and inflammatory cytokines by using Western blot, q-PCR, and immunofluorescence. Furthermore, brain electrical activity in freely moving mice was recorded by electroencephalography (EEG). TRPV1 current and neuronal excitability were detected by whole-cell patch clamp. RESULTS: Astrocytic TRPV1 translocated to the membrane after OGD. Mechanistically, astrocytic TRPV1 activation increased the inflow of Ca2+, which promoted G-actin polymerized to F-actin, thus promoted astrocyte migration after OGD. Moreover, astrocytic TRPV1 deficiency decreased the production and release of pro-inflammatory cytokines (TNF, IL-6, IL-1ß, and iNOS) after OGD. It could also dramatically attenuate neuronal excitability after OGD and brain electrical activity in HIBD mice. Behavioral testing for seizures after HIBD revealed that TRPV1 knockout mice demonstrated prolonged onset latency, shortened duration, and decreased seizure severity when compared with wild-type mice. CONCLUSIONS: Collectively, TRPV1 promoted astrocyte migration thus helped the infiltration of pro-inflammatory cytokines (TNF, IL-1ß, IL-6, and iNOS) from astrocytes into the vicinity of neurons to promote epilepsy. Our study provides a strong rationale for astrocytic TRPV1 to be a therapeutic target for anti-epileptogenesis after HIBD.

Judicial improvement, market integration, and export technical complexity-a quasi-natural experiments based on the creation of circuit courts.

Judicial improvement and trade structure optimization are important elements in achieving a high level of openness. This paper develops a theoretical framework on the impact of local protectionism on market integration and export technical complexity, and then empirically analyses the effect of judicial improvement on the technical complexity of urban product exports and its mechanism of action based on a quasi-natural experiment with the establishment of circuit courts. The study finds that the establishment of circuit courts significantly increases the technical complexity of product exports, and the findings remain valid after a series of robustness tests. Further analysis shows that the technology enhancement effect of the establishment of circuit courts is more pronounced in the group of cities with higher administrative levels, better location advantages, and less advanced rule of law. Mechanism Analysis shows that a superior institutional environment can have a two-sided effect on different types of firms. Overall, however, the productivity-enhancing effect of low-productivity firms exiting the market is lower than the productivity-reducing effect of higher-productivity firms' increased compliance costs, which in turn weakens the positive promotional effect of circuit courts. The above theoretical and empirical findings provide policy implications for maximizing the technology enhancement effect of the establishment of circuit courts on product exports, thereby promoting a high level of openness in China.

Transient Receptor Potential Vanilloid 4: a Double-Edged Sword in the Central Nervous System.

Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel that can be activated by diverse stimuli, such as heat, mechanical force, hypo-osmolarity, and arachidonic acid metabolites. TRPV4 is widely expressed in the central nervous system (CNS) and participates in many significant physiological processes. However, accumulative evidence has suggested that deficiency, abnormal expression or distribution, and overactivation of TRPV4 are involved in pathological processes of multiple neurological diseases. Here, we review the latest studies concerning the known features of this channel, including its expression, structure, and its physiological and pathological roles in the CNS, proposing an emerging therapeutic strategy for CNS diseases.

In Situ Construction of Heterostructured Co3O4/CoP Nanoflake Arrays on Carbon Cloth as Binder-Free Anode for High-Performance Lithium-Ion Batteries.

Cobalt oxide (Co3O4) is regarded as the anode material for lithium-ion batteries (LIBs) with great research value owing to its environmental friendliness and exceptional theoretical capacity. However, the low intrinsic conductivity, poor electrochemical kinetics, and unsatisfactory cycling performance severely limit its practical applications in LIBs. The construction of a self-standing electrode with heterostructure by introducing a highly conductive cobalt-based compound is an effective strategy to solve the above issues. Herein, Co3O4/CoP nanoflake arrays (NFAs) with heterostructure are constructed skillfully directly grown on carbon cloth (CC) by in situ phosphorization as an anode for LIBs. Density functional theory simulation results demonstrate that the construction of heterostructure greatly increases the electronic conductivity and Li ion adsorption energy. The Co3O4/CoP NFAs/CC exhibited an extraordinary capacity (1490.7 mA h g-l at 0.1 A g-l) and excellent performance at high current density (769.1 mA h g-l at 2.0 A g-l), as well as remarkable cyclic stability (451.3 mA h g-l after 300 cycles with a 58.7% capacity retention rate). The reasonable construction of heterostructure can promote the interfacial ion transport, significantly enhance the adsorption energy of lithium ions, improve the conductivity of Co3O4 electrode material, promote the partial charge transfer throughout the charge and discharge cycles, and enhance the overall electrochemical performance of the material.

Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates Seizures.

Astrocytes are critical regulators of the immune/inflammatory response in several human central nervous system (CNS) diseases. Emerging evidence suggests that dysfunctional astrocytes are crucial players in seizures. The objective of this study was to investigate the role of transient receptor potential vanilloid 4 (TRPV4) in 4-aminopyridine (4-AP)-induced seizures and the underlying mechanism. We also provide evidence for the role of Yes-associated protein (YAP) in seizures. 4-AP was administered to mice or primary cultured astrocytes. YAP-specific small interfering RNA (siRNA) was administered to primary cultured astrocytes. Mouse brain tissue and surgical specimens from epileptic patient brains were examined, and the results showed that TRPV4 was upregulated, while astrocytes were activated and polarized to the A1 phenotype. The levels of glial fibrillary acidic protein (GFAP), cytokine production, YAP, signal transducer activator of transcription 3 (STAT3), intracellular Ca2+([Ca2+]i) and the third component of complement (C3) were increased in 4-AP-induced mice and astrocytes. Perturbations in the immune microenvironment in the brain were balanced by TRPV4 inhibition or the manipulation of [Ca2+]i in astrocytes. Knocking down YAP with siRNA significantly inhibited 4-AP-induced pathological changes in astrocytes. Our study demonstrated that astrocytic TRPV4 activation promoted neuroinflammation through the TRPV4/Ca2+/YAP/STAT3 signaling pathway in mice with seizures. Astrocyte TRPV4 inhibition attenuated neuroinflammation, reduced neuronal injury, and improved neurobehavioral function. Targeting astrocytic TRPV4 activation may provide a promising therapeutic approach for managing epilepsy.

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1.

Epilepsy is a brain condition characterized by the recurrence of unprovoked seizures. Recent studies have shown that complement component 3 (C3) aggravate the neuronal injury in epilepsy. And our previous studies revealed that TRPV1 (transient receptor potential vanilloid type 1) is involved in epilepsy. Whether complement C3 regulation of neuronal injury is related to the activation of TRPV1 during epilepsy is not fully understood. We found that in a mouse model of status epilepticus (SE), complement C3 derived from astrocytes was increased and aggravated neuronal injury, and that TRPV1-knockout rescued neurons from the injury induced by complement C3. Circular RNAs are abundant in the brain, and the reduction of circRad52 caused by complement C3 promoted the expression of TRPV1 and exacerbated neuronal injury. Mechanistically, disorders of neuron-glia interaction mediated by the C3-TRPV1 signaling pathway may be important for the induction of neuronal injury. This study provides support for the hypothesis that the C3-TRPV1 pathway is involved in the prevention and treatment of neuronal injury and cognitive disorders.

Training to improve the physical fitness of table tennis players / Treinamento para melhorar a aptidão física de jogadores de tênis de mesa / Entrenamiento para mejorar la condición física de los jugadores de tenis de mesa

ABSTRACT Introduction: Table tennis is a technical game with nets. The direction changes, ball accelerations, and considerable extensions of table tennis make it more expressive. Physical training is an essential step of physical preparation by contemporary Chinese players. Objective: Discuss the effects of physical training on table tennis players. Methods: A randomized collection was used to select 16 table tennis players. A training follow-up was conducted for one year, with exercises three times a week. Training intensity data and success rate of hitting evolution were statistically analyzed. Results: The ability of table tennis players was improved after one year of physical training under the presented protocol(P<0.05). There was no significant difference in lactate, heart rate, and success rate before and after the intervention(P<0.05). Conclusion: Physical training is essential to improve the energy delivery systems of phosphagen, phosphagen glycolysis, and glycolysis. Physical training is the key to improving table tennis players' performance and physical quality. Coaches can use the results of this article to monitor the special physical training of athletes. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: O tênis de mesa é um jogo de técnica com redes. As mudanças de direção, acelerações da bola e extensões consideráveis do tênis de mesa o tornam mais expressivo. O treinamento físico é uma etapa essencial da preparação física por parte dos jogadores chineses contemporâneos. Objetivo: Discutir os efeitos do treinamento físico sobre os jogadores de tênis de mesa. Métodos: Utilizou-se uma coleta aleatória para selecionar 16 jogadores de tênis de mesa. Foi realizado um acompanhamento de treinamento por um ano, com exercícios três vezes por semana. Os dados de intensidade do treinamento e a taxa de sucesso da evolução dos acertos foram analisados estatisticamente. Resultados: A habilidade dos jogadores de tênis de mesa foi aprimorada após um ano de treinamento físico sob o protocolo apresentado(P<0,05). Não houve diferença significativa no lactato, frequência cardíaca e taxa de sucesso antes e depois da intervenção(P<0,05). Conclusão: O treinamento físico é essencial para melhorar os sistemas de fornecimento de energia de fosfágeno, glicólise de fosfágeno e glicólise. O treinamento físico evidenciou ser a chave para melhorar o desempenho e a qualidade física dos jogadores de tênis de mesa. Os treinadores podem utilizar os resultados deste artigo para monitorar o treinamento físico especial dos atletas. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: El tenis de mesa es un juego técnico con redes. Los cambios de dirección, las aceleraciones de la pelota y las considerables extensiones del tenis de mesa lo hacen más expresivo. El entrenamiento físico es un paso esencial de la preparación física de los jugadores chinos contemporáneos. Objetivo: Discutir los efectos del entrenamiento físico en los jugadores de tenis de mesa. Métodos: Se utilizó una colección aleatoria para seleccionar 16 jugadores de tenis de mesa. Se realizó un seguimiento del entrenamiento durante un año, con ejercicios tres veces por semana. Se analizaron estadísticamente los datos de la intensidad del entrenamiento y la tasa de éxito de la evolución de los golpes. Resultados: La capacidad de los jugadores de tenis de mesa mejoró tras un año de entrenamiento físico con el protocolo presentado (P<0,05). No hubo diferencias significativas en el lactato, la frecuencia cardíaca y la tasa de éxito antes y después de la intervención (P<0,05). Conclusión: El entrenamiento físico es esencial para mejorar los sistemas de suministro de energía del fosfágeno, la glucólisis del fosfágeno y la glucólisis. El entrenamiento físico ha demostrado ser la clave para mejorar el rendimiento y la calidad física de los jugadores de tenis de mesa. Los entrenadores pueden utilizar los resultados de este artículo para controlar la preparación física especial de los deportistas. Nivel de evidencia II; Estudios terapéuticos -investigación de los resultados del tratamiento.

Application of the overhead training method in sportsmen / Aplicação do método de treinamento suspenso nos esportistas / Aplicación del método de entrenamiento en suspensión en deportistas

ABSTRACT Introduction: Suspension training is a new activity in which exercises are performed exploring the body weight as resistance, using a suspension tape. The body remains in constant motion due to the support reaction force formed by the open kinetic chain, requiring rapid muscle contractions for continuous balance adjustment. It is believed that this training can improve proprioceptive neuromuscular function, although there is little scientific evidence of its benefits on body posture in athletes. Objective: Explore the function and application of the overhead training method in athletes. Methods: Sixteen male athletes from a provincial badminton team volunteered for the research. Divided into two groups, the experimental group added suspension training. In contrast, the control group kept only traditional training, the other training contents were the same between the two groups, and the experiment lasted 12 weeks. The relevant data were collected before and after the intervention period by the GoodBalance balance tester, and the balance ability of all athletes with eyes closed on one foot was evaluated. Results: The balance ability of the athletes in the experimental group was significantly improved, while the balance ability of the athletes in the control group changed little. Conclusion: Suspension training can significantly improve the balance ability of athletes and can be used as an effective auxiliary training method for balance improvement. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO IIntrodução: O treinamento suspenso é uma nova forma de atividade na qual se realiza exercícios explorando o peso corporal como resistência, utilizando uma fita de suspensão. O corpo permanece em constante movimento, devido à força de reação de apoio formada pela cadeia cinética aberta, exigindo contrações musculares rápidas para ajuste contínuo do equilíbrio. Acredita-se que esse treinamento possa melhorar a função proprioceptiva neuromuscular, embora haja poucas evidências científicas de seus benefícios sobre a postura corporal em esportistas. Objetivo: Explorar a função e a aplicação do método de treinamento suspenso nos esportistas. Métodos: 16 atletas masculinos da equipe de badminton de uma província foram voluntários para a pesquisa. Divididos em dois grupos, ao grupo experimental adicionou-se o treinamento em suspensão enquanto o grupo controle manteve apenas o treinamento tradicional, os outros conteúdos de treinamento foram exatamente os mesmos entre os dois grupos, o experimento durou 12 semanas. Os dados relevantes foram coletados antes e após o período de intervenção pelo testador de equilíbrio GoodBalance, a habilidade de equilíbrio de todos os atletas com os olhos fechados em um pé foi avaliada. Resultados: A habilidade de equilíbrio dos esportistas no grupo experimental foi significativamente aprimorada, enquanto a habilidade de equilíbrio dos atletas no grupo de controle sofreu poucas alterações. Conclusão: O treinamento de suspensão pode melhorar significativamente a capacidade de equilíbrio dos esportistas, podendo ser usado como um método de treinamento auxiliar eficaz para o aprimoramento de equilíbrio. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: El entrenamiento en suspensión es una nueva forma de actividad en la que se realizan ejercicios explorando el peso del cuerpo como resistencia, utilizando una cinta de suspensión. El cuerpo se mantiene en constante movimiento, debido a la fuerza de reacción de apoyo formada por la cadena cinética abierta, exigiendo rápidas contracciones musculares para el ajuste continuo del equilibrio. Se cree que este entrenamiento puede mejorar la función neuromuscular propioceptiva, aunque hay pocas pruebas científicas de sus beneficios sobre la postura corporal en los deportistas. Objetivo: Explorar la función y la aplicación del método de entrenamiento por encima de la cabeza en los deportistas. Métodos: 16 atletas masculinos de un equipo provincial de bádminton se ofrecieron como voluntarios para la investigación. Divididos en dos grupos, al grupo experimental se le añadió el entrenamiento en suspensión mientras que el grupo de control mantuvo sólo el entrenamiento tradicional, los demás contenidos del entrenamiento fueron exactamente los mismos entre los dos grupos, el experimento duró 12 semanas. Los datos relevantes se recogieron antes y después del periodo de intervención mediante el probador de equilibrio GoodBalance, y se evaluó la capacidad de equilibrio de todos los atletas con los ojos cerrados sobre un pie. Resultados: La capacidad de equilibrio de los atletas del grupo experimental mejoró significativamente, mientras que la capacidad de equilibrio de los atletas del grupo de control sufrió pocos cambios. Conclusión: El entrenamiento en suspensión puede mejorar significativamente la capacidad de equilibrio de los atletas, y puede utilizarse como un método de entrenamiento auxiliar eficaz para mejorar el equilibrio. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.