Detalhe da pesquisa
1.
PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response.
J Biol Chem
; 295(1): 237-249, 2020 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31792031
2.
FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits.
Hum Mol Genet
; 28(22): 3777-3791, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31509188
3.
Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.
Hum Mol Genet
; 27(22): 3951-3963, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30137327
4.
World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia.
Alzheimers Dement
; 16(7): 1078-1094, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32627328
5.
Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice.
Brain Behav Immun
; 80: 344-357, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30980950
6.
Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke.
Brain Behav Immun
; 75: 34-47, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30195027
7.
Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before: ApoE, APP transcription and AD: Hypothesised mechanisms and existing knowledge gaps.
Bioessays
; 39(9)2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28731260
8.
Systemic toxicity of di (2-ethylhexyl) adipate (DEHA) in rats following 28-day intravenous exposure.
Regul Toxicol Pharmacol
; 104: 50-55, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30826316
9.
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
J Neurosci
; 37(21): 5345-5365, 2017 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28450540
10.
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
Nature
; 482(7384): 216-20, 2012 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22278060
11.
Emerging therapeutics for Alzheimer's disease.
Annu Rev Pharmacol Toxicol
; 54: 381-405, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24392696
12.
Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice.
Biochem Biophys Res Commun
; 478(1): 286-292, 2016 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27425247
13.
The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes.
Acta Neuropathol
; 129(1): 1-19, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25287911
14.
Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid ß-protein oligomers.
Traffic
; 13(5): 681-93, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22309053
15.
Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice.
J Neurosci
; 33(39): 15596-602, 2013 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24068826
16.
Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.
Biochemistry
; 53(12): 1947-57, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24620716
17.
γ-Secretase inhibitors and modulators.
Biochim Biophys Acta
; 1828(12): 2898-907, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23791707
18.
Steroids as γ-secretase modulators.
FASEB J
; 27(9): 3775-85, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23716494
19.
Substrate-targeting gamma-secretase modulators.
Nature
; 453(7197): 925-9, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18548070
20.
Localized APP expression results in progressive network dysfunction by disorganizing spike timing.
Neuron
; 112(1): 124-140.e6, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37909036