Detalhe da pesquisa
1.
Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor.
Bioorg Med Chem Lett
; 80: 129120, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36587872
2.
Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists.
J Org Chem
; 81(21): 10383-10391, 2016 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27462910
3.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres.
Bioorg Med Chem
; 24(16): 3842-8, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27364611
4.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents.
Bioorg Med Chem
; 23(19): 6379-88, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26342544
5.
Isolation of Hemiketal and Hydroxy Ketone Tautomers of Synthetic Intermediates Each Affording 18-Hydroxycortisol-1,6,7-d3.
ACS Omega
; 8(31): 28185-28195, 2023 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37576635
6.
Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist.
ACS Chem Neurosci
; 13(7): 1082-1095, 2022 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35325532
7.
Design, synthesis and biological evaluation of a bi-specific vaccine against α-pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats.
Vaccine
; 38(2): 336-344, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31629568
8.
FerriBRIGHT: a rationally designed fluorescent probe for redox active metals.
J Am Chem Soc
; 131(24): 8578-86, 2009 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19459701
9.
Assessment and use of two silicon carbide multi-well plates for library synthesis and proteolytic digests using microwave heating.
Org Biomol Chem
; 7(11): 2452-7, 2009 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19462057
10.
Flash column chromatograms estimated from thin-layer chromatography data.
J Chromatogr A
; 1211(1-2): 49-54, 2008 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18849041
11.
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic).
J Med Chem
; 61(17): 7546-7559, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30032602
12.
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic).
J Med Chem
; 61(17): 7525-7545, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30117738
13.
Simple Tetrahydroisoquinolines Are Potent and Selective Kappa Opioid Receptor Antagonists.
ACS Med Chem Lett
; 8(7): 742-745, 2017 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28740609
14.
Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile.
J Med Chem
; 57(17): 7367-81, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25133923
15.
Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines.
J Med Chem
; 57(7): 3140-7, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24635568
16.
Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists.
J Med Chem
; 56(11): 4551-67, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23651437
17.
Preparation of nonsymmetrically substituted stilbenes in a one-pot two-step heck strategy using ethene as a reagent.
J Org Chem
; 73(10): 3854-8, 2008 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-18410149
18.
Alkoxycarbonylation of aryl iodides using gaseous carbon monoxide and pre-pressurized reaction vessels in conjunction with microwave heating.
Org Biomol Chem
; 5(1): 65-8, 2007 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-17164908