Detalhe da pesquisa
1.
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain.
Bioorg Med Chem
; 63: 116743, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35436748
2.
Inhibition of Interleukin-23-Mediated Inflammation with a Novel Small Molecule Inverse Agonist of RORγt.
J Pharmacol Exp Ther
; 371(1): 208-218, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31375639
3.
Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists.
Bioorg Med Chem Lett
; 29(14): 1799-1806, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31101472
4.
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents.
J Neurosci
; 34(13): 4445-52, 2014 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24671991
5.
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo.
J Med Chem
; 66(6): 3852-3865, 2023 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36877935
6.
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.
J Pharmacol Exp Ther
; 342(2): 416-28, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22570364
7.
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats.
Mol Pain
; 6: 14, 2010 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20205719
8.
Synthesis of oxazolo[4,5-c]quinoline TRPV1 antagonists.
J Org Chem
; 75(24): 8713-5, 2010 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21090730
9.
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Bioorg Med Chem Lett
; 20(22): 6812-5, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855211
10.
Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists.
Bioorg Med Chem
; 18(13): 4821-9, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20570528
11.
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
Bioorg Med Chem
; 18(22): 7816-25, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20965738
12.
Molecular determinants of species-specific activation or blockade of TRPA1 channels.
J Neurosci
; 28(19): 5063-71, 2008 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18463259
13.
IL-23 induces regulatory T cell plasticity with implications for inflammatory skin diseases.
Sci Rep
; 9(1): 17675, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31776355
14.
A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.
J Pharmacol Exp Ther
; 324(3): 1204-11, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18089840
15.
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
J Med Chem
; 51(3): 407-16, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18176998
16.
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.
Bioorg Med Chem
; 16(12): 6379-86, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18501613
17.
Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.
J Med Chem
; 50(24): 6265-73, 2007 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17973362
18.
TRPV1 antagonists: clinical setbacks and prospects for future development.
Prog Med Chem
; 51: 57-70, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22520471
19.
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.
J Med Chem
; 49(23): 6869-87, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17154517
20.
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.
J Med Chem
; 49(12): 3659-66, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759108