Detalhe da pesquisa
1.
Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
Nat Chem Biol
; 13(6): 675-680, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28437394
2.
Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors.
Bioorg Med Chem
; 22(19): 5513-29, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25139751
3.
Identification of a novel ALDH1A3-selective inhibitor by a chemical probe with unrelated bioactivity: An approach to affinity-based drug target discovery.
Chem Biol Drug Des
; 101(3): 727-739, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36334047
4.
Stereochemistry of pladienolide B.
J Antibiot (Tokyo)
; 60(6): 364-9, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17617693
5.
Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61.
Mol Cancer Ther
; 15(6): 1208-16, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27196783
6.
Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.
Mol Cancer Ther
; 1(3): 169-75, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12467211
7.
Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking.
Cancer Biol Ther
; 16(4): 589-601, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25729885
8.
[Discovery of splicing inhibitors and its impact on drug development].
Tanpakushitsu Kakusan Koso
; 53(1): 28-35, 2008 Jan.
Artigo
em Japonês
| MEDLINE | ID: mdl-18186300
9.
Total synthesis of the potent antitumor macrolides pladienolide B and D.
Angew Chem Int Ed Engl
; 46(23): 4350-5, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17437311
10.
Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor.
Int J Mol Med
; 29(4): 541-9, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22211243
11.
Biological validation that SF3b is a target of the antitumor macrolide pladienolide.
FEBS J
; 278(24): 4870-80, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21981285
12.
Splicing factor SF3b as a target of the antitumor natural product pladienolide.
Nat Chem Biol
; 3(9): 570-5, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17643112
13.
A novel carbazole topoisomerase II poison, ER-37328: potent tumoricidal activity against human solid tumors in vitro and in vivo.
Cancer Sci
; 94(1): 119-24, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12708485
14.
Synthesis and evaluation of novel pyrimido-acridone, -phenoxadine, and -carbazole as topoisomerase II inhibitors.
Chem Pharm Bull (Tokyo)
; 52(9): 1071-81, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15340192