[Changes in the rheologic properties of erythrocytes in various hematologic diseases]. / Izmeneniia nekotorykh reologicheskikh svoistv eritrotsitov pri riade zabolevanii sistemy krovi.

Some rheological properties of red blood cells were investigated in certain hematological diseases, considering the factors inducing disorders in red blood cell aggregation, deformability and viscosity. It has been shown that these disorders are responsible for increased blood viscosity and microcirculatory disorders in some blood diseases. The changes in red blood cell rheological properties play a significant role in the pathogenesis of thrombohemorrhagic complications in certain hematological diseases. The study of rheological mechanisms regulating blood circulation is necessary for successful development of optimal programs for combined treatment of hematological patients.

[Role of drugs with disaggregative effect in the prevention of thrombosis in reconstructive operations on the veins of the limbs]. / O roli preparatov dezagregiruiushchego deistviia v preduprezhdenii trombozov pri rekonstruktivnykh operatsiiakh na venakh konechnostei

With the aim of prophylaxis of early postoperative thrombosis in reparative operations on veins of the lower extremities acetyl salicylic acid (aspirin) was used. Diminishing of adhesion and aggregation of thrombocytes, a reduced fibrinase activity and lessening of clot density were noted.

[A modification of a method of evaluating the coagulation activity of factor VIII]. / Modifitatsiia metoda otsenki koaguliatsionnoi aktivnosti faktora VIII.

The authors suggest that factor VIII activity be calculated relative to the value of activated partial thromboplastin time of substrate hemophilic plasma. This value is determined by replacing the tested plasma in the reaction mixture with veronal-acetate buffer. This modification has been developed to eliminate the shortcomings of the single-step technique for measuring this factor activity, that are explained by the use of nonstandard donor plasma and by the necessity to have such plasma during the investigation. A formula has been derived for the calculation of factor VIII coagulation activity in hemophilic patients and the advantages of the suggested modification are demonstrated.