Detalhe da pesquisa
1.
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature
; 550(7677): 481-486, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29045389
2.
Structural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites.
Nature
; 508(7496): 416-9, 2014 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24670664
3.
Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex.
EMBO J
; 31(6): 1568-78, 2012 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22307084
4.
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
J Med Chem
; 65(20): 13879-13891, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36200480
5.
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
Elife
; 102021 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34636321
6.
Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery.
Bioorg Med Chem
; 16(10): 5501-13, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18462943
7.
Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta".
J Med Chem
; 2023 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36815444
8.
Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase.
Comb Chem High Throughput Screen
; 10(9): 783-9, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18478959
9.
Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors.
J Mol Biol
; 393(2): 504-13, 2009 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19695264
10.
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J Mol Biol
; 375(1): 217-28, 2008 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18005987
11.
Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights.
Proc Natl Acad Sci U S A
; 102(30): 10499-504, 2005 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16027359