RESUMO
Background and aim: Adenoid cystic carcinoma is one of the most common malignant neoplasms of the salivary gland. It has overlapping histological features with other salivary gland tumors. MYB is a nuclear marker which is known to be expressed in Adenoid cystic carcinoma. In this study we aim to determine the sensitivity and specificity of MYB IHC marker to differentiate Adenoid cystic carcinoma from other benign and malignant salivary gland tumors. Materials and method: This is a retrospective case control study on the paraffin blocks of 78 cases of salivary gland tumors obtained over a period of 5 years. MYB Ser11 monoclonal antibody of clone SZ04-81 IHC, a nuclear marker was done on all cases. The results observed was tabulated and statistical analysis was done to calculate the sensitivity and specificity of the MYB IHC marker. Results: The mean age group of Adenoid cystic carcinoma was 45 years with a female preponderance. 60% of the cases of Adenoid cystic carcinoma were from minor salivary glands spread across various sites. The sensitivity and specificity of the MYB IHC marker were statistically analyzed and found to be 93.9% and 97.8% respectively. Conclusion: The present study shows substantial expression of MYB immunohistochemical marker in Adenoid cystic carcinoma, with a very high sensitivity and specificity obtained using the clone SZ04-81. Thus this marker can be used in the diagnosis of adenoid cystic carcinoma. However, correlation with H & E and FISH studies are required. Supplementary Information: The online version contains supplementary material available at 10.1007/s12070-023-03471-4.
RESUMO
Primary epithelial tumour of the renal pelvis is a rare entity. So far, very few cases are reported in literature. Of these, mucin secreting adenocarcinomas are distinctly rare. However, mucinous cystadenocarcinoma, that too arising in a horse shoe kidney is extremely rare to be reported. Mucinous cystadenomas and carcinomas arising from the renal pelvis are regarded to be secondary to a metaplastic change in the urothelium. Here, we present a case of a 51-year-old male, who complained of abdominal pain, palpable abdominal mass, haematuria along with passage of mucoid material in the urine, with a very poorly functioning kidney. A pre-operative diagnosis of horse shoe kidney with pelvi ureteric junction obstruction and a poorly functioning kidney was made. Intraoperative findings and frozen section biopsy were suggestive of mucin secreting cystic mass and a right heminephrectomy was done. The final histopathology was suggestive of mucinous cystadenocarcinoma of the renal pelvis of the right moiety. This case is presented for its rarity, diagnostic challenges faced and the lessons learnt, stressing on the need for having a high index of clinical suspicion in making such diagnosis.