Detalhe da pesquisa
1.
Sex-specific hypnotic effects of the neuroactive steroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid.
Br J Anaesth
; 130(2): 154-164, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36428160
2.
A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol.
J Neurosci
; 41(49): 10054-10064, 2021 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34725187
3.
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.
Immunity
; 38(1): 106-18, 2013 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23273843
4.
Differential effects of the novel neurosteroid hypnotic (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats.
Br J Anaesth
; 127(3): 435-446, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-33972091
5.
The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile.
Br J Anaesth
; 126(1): 245-255, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32859366
6.
Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain.
Br J Anaesth
; 124(5): 603-613, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32151384
7.
Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking.
J Lipid Res
; 60(3): 707-716, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617147
8.
Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.
J Biol Chem
; 293(8): 3013-3027, 2018 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29301936
9.
Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum.
Br J Anaesth
; 122(5): 643-651, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30916017
10.
Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.
J Biol Chem
; 292(22): 9294-9304, 2017 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28396346
11.
Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.
Anal Chem
; 89(4): 2636-2644, 2017 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28194953
12.
Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1ß2γ2L GABA(A) Receptors.
Mol Pharmacol
; 89(4): 399-406, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26769414
13.
A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.
J Lipid Res
; 56(12): 2408-19, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26497473
14.
Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling.
Biochemistry
; 53(18): 3042-51, 2014 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24758724
15.
Oxysterols are allosteric activators of the oncoprotein Smoothened.
Nat Chem Biol
; 8(2): 211-20, 2012 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22231273
16.
The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy.
Front Pharmacol
; 13: 855779, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35370641
17.
Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3ß-OH.
Front Pharmacol
; 13: 850658, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35677453
18.
Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites.
Elife
; 112022 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34982031
19.
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Sci Adv
; 8(22): eabm5563, 2022 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35658032
20.
Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells.
Sci Rep
; 11(1): 8927, 2021 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33903617