Detalhe da pesquisa
1.
Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo.
PLoS Pathog
; 19(10): e1011496, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37871122
2.
Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin.
Proc Natl Acad Sci U S A
; 117(12): 6792-6800, 2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32152097
3.
Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin.
J Biol Chem
; 295(17): 5614-5625, 2020 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32156702
4.
Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis.
Infect Immun
; 89(4)2021 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33468584
5.
Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function.
J Biol Chem
; 294(19): 7644-7657, 2019 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30918026
6.
A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.
J Biol Chem
; 293(3): 941-952, 2018 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180448
7.
Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.
J Biol Chem
; 292(35): 14401-14412, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28705932
8.
Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.
J Biol Chem
; 292(42): 17290-17301, 2017 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28842504
9.
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.
Infect Immun
; 84(3): 856-65, 2016 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26755157
10.
Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein.
J Biol Chem
; 287(46): 39149-57, 2012 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23012355
11.
The USP46 complex deubiquitylates LRP6 to promote Wnt/ß-catenin signaling.
Nat Commun
; 14(1): 6173, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37798301
12.
Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.
J Biol Chem
; 286(26): 23345-56, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21531712
13.
Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin.
Proc Natl Acad Sci U S A
; 106(19): 7786-91, 2009 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19416890
14.
Skizzle is a novel plasminogen- and plasmin-binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation.
J Biol Chem
; 285(27): 21153-64, 2010 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20435890
15.
Control of antiviral innate immune response by protein geranylgeranylation.
Sci Adv
; 5(5): eaav7999, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31149635
16.
Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.
J Mol Biol
; 429(7): 1030-1044, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28232034
17.
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.
Nat Med
; 17(9): 1142-6, 2011 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21857652
18.
Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.
J Biol Chem
; 282(22): 16095-104, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17430903
19.
Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions.
J Biol Chem
; 281(2): 1169-78, 2006 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16230340
20.
Solution structure of the cytoplasmic domain of erythrocyte membrane band 3 determined by site-directed spin labeling.
Biochemistry
; 44(46): 15115-28, 2005 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16285715