Detalhe da pesquisa
1.
Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.
Nucleic Acids Res
; 51(10): 5255-5270, 2023 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37115000
2.
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature
; 510(7505): 422-426, 2014 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24814345
3.
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
J Am Chem Soc
; 141(22): 8951-8968, 2019 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31060360
4.
Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Biochem J
; 474(5): 699-713, 2017 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28057719
5.
Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design.
Hum Mol Genet
; 24(20): 5667-76, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26199317
6.
Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.
Proc Natl Acad Sci U S A
; 111(31): 11341-6, 2014 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25049398
7.
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
J Biol Chem
; 288(11): 7803-7814, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23349464
8.
Structural basis for the regulated protease and chaperone function of DegP.
Nature
; 453(7197): 885-90, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18496527
9.
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Proc Natl Acad Sci U S A
; 108(19): 7745-50, 2011 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21508329
10.
Squeezing the most from every crystal: the fine details of data collection.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 7): 1303-13, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23793157
11.
Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
Biochemistry
; 51(25): 5083-90, 2012 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22642810
12.
Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.
J Biol Chem
; 286(35): 30680-30690, 2011 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21685389
13.
Experiences From Developing Software for Large X-Ray Crystallography-Driven Protein-Ligand Studies.
Front Mol Biosci
; 9: 861491, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35480897
14.
Of problems and opportunities-How to treat and how to not treat crystallographic fragment screening data.
Protein Sci
; 31(9): e4391, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36040268
15.
Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening.
Front Chem
; 10: 844598, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35601556
16.
Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16.
RSC Chem Biol
; 3(1): 44-55, 2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35128408
17.
Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects.
J Synchrotron Radiat
; 18(Pt 3): 387-97, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21525647
18.
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins.
Proc Natl Acad Sci U S A
; 105(22): 7702-7, 2008 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-18505836
19.
Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space.
J Med Chem
; 64(24): 17887-17900, 2021 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34898210
20.
Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
ACS Chem Biol
; 16(4): 586-595, 2021 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33724769