Detalhe da pesquisa
1.
Pharmacokinetics and safety of letermovir, a novel anti-human cytomegalovirus drug, in patients with renal impairment.
Br J Clin Pharmacol
; 83(9): 1944-1953, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28345163
2.
Pharmacokinetics and safety of the anti-human cytomegalovirus drug letermovir in subjects with hepatic impairment.
Br J Clin Pharmacol
; 83(12): 2678-2686, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28722153
3.
Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes simplex virus 1 infection model.
Antimicrob Agents Chemother
; 58(7): 3843-52, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24752278
4.
Evaluation of the Clinical Drug-Drug Interaction Potential of Pritelivir on Transporters and CYP450 Enzymes Using a Cocktail Approach.
Clin Pharmacol Drug Dev
; 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38752475
5.
Mass Balance and Metabolite Profile after Single and Multiple Oral Doses of Pritelivir in Healthy Subjects.
Clin Pharmacol Drug Dev
; 13(4): 389-403, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38189209
6.
First-in-Human, Single- and Multiple-Ascending-Dose, Food-Effect, and Absolute Bioavailability Trials to Assess the Pharmacokinetics, Safety, and Tolerability of Pritelivir, a Nonnucleoside Helicase-Primase Inhibitor Against Herpes Simplex Virus in Healthy Subjects.
Clin Pharmacol Drug Dev
; 12(7): 749-760, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36860173
7.
Pharmacokinetics and Safety of Letermovir and Midazolam Coadministration in Healthy Subjects.
Clin Pharmacol Drug Dev
; 11(1): 16-24, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34714967
8.
Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections.
J Med Chem
; 65(20): 13614-13628, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36202389
9.
The Effect of Oral Letermovir Administration on the Pharmacokinetics of a Single Oral Dose of P-Glycoprotein Substrate Digoxin in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 11(1): 6-15, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34812580
10.
Absorption, Metabolism, Distribution, and Excretion of Letermovir.
Curr Drug Metab
; 22(10): 784-794, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33622223
11.
Pharmacokinetics and Safety of Letermovir Coadministered With Cyclosporine A or Tacrolimus in Healthy Subjects.
Clin Pharmacol Drug Dev
; 7(1): 9-21, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28967706