Detalhe da pesquisa
1.
Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist.
J Pharmacol Exp Ther
; 343(1): 233-45, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22815533
2.
A robust and high-capacity [(35)S]GTPgammaS binding assay for determining antagonist and inverse agonist pharmacological parameters of histamine H(3) receptor ligands.
Assay Drug Dev Technol
; 6(3): 339-49, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18593375
3.
An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity.
J Pharmacol Exp Ther
; 323(3): 888-98, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17855474
4.
Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists.
J Med Chem
; 50(22): 5439-48, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918921
5.
Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity.
Biochem Pharmacol
; 73(8): 1243-55, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17371699
6.
Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand.
Br J Pharmacol
; 148(5): 657-70, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16715122
7.
Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist.
Biochem Pharmacol
; 68(5): 933-45, 2004 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15294456
8.
Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist.
Eur J Pharmacol
; 487(1-3): 183-97, 2004 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15033391
9.
Genetic and pharmacological aspects of histamine H3 receptor heterogeneity.
Life Sci
; 73(24): 3043-72, 2003 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-14550847
10.
In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
Basic Clin Pharmacol Toxicol
; 95(3): 144-52, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15447739
11.
The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
J Med Chem
; 51(17): 5423-30, 2008 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18683917
12.
G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations.
J Pharmacol Exp Ther
; 314(1): 271-81, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15821027
13.
Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties.
J Pharmacol Exp Ther
; 313(1): 165-75, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15608078
14.
Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist.
J Pharmacol Exp Ther
; 313(1): 176-90, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15608077
15.
Differential activation of dual signaling responses by human H1 and H2 histamine receptors.
J Recept Signal Transduct Res
; 23(1): 17-31, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12680587
16.
Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects.
J Pharmacol Exp Ther
; 305(3): 887-96, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12606603