[Association of Polymorphic Genome Variants in the 2q32.1 Locus with the Development of Vasovagal Syncope].

The vasovagal syncope (VVS) is the most common form of syncope. The mechanisms of VVS development are not entirely clear. It is known that there is a genetic predisposition to this disease, but the data on the roles of individual genes are quite contradictory. Recently, a genome-wide association study identified a locus at chromosome 2q32.1 associated with a united group of diseases, that is, syncope and collapse; among the single nucleotide polymorphisms (SNPs) of this locus, the most significant association was observed for rs12465214. In a homogeneous sample of patients diagnosed with VVS, we analyzed the association of rs12465214, rs12621296, rs17582219 and rs1344706 located on chromosome 2q32.1 with this form of syncope. In the enrolled set, only rs12621296 was associated with VVS by itself, whereas associations of other SNPs were observed only in biallelic combinations. An epistatic interaction between the components of the combination rs12621296*A + rs17582219*A was revealed. The possible involvement of individual genes on the 2q32.1 locus in the genetic architecture of the VVS is discussed.

[Lifestyle Modification as a Method of Treatment of Vasovagal Syncope].

Vasovagal syncope is the most common cause for loss of consciousness. The need for treatment of this condition is warranted by impaired quality of life and a risk of trauma due to the fall. At present, there are no medications with proven preventive effectiveness for vasovagal syncope as demonstrated by large randomized, placebo-controlled studies.  At the same time, information about the pathogenesis of vasovagal reaction and provoking factors allows effective use of non-drug methods (such as patient education, physical exercise, maneuvers) in the management of patients with vasovagal syncope.

[Efficasy of compression therapy of the lower limbs in the treatment of patients with vasovagal syncopes].

AIM: To study efficacy and tolerance of compressive textile in the treatment of vasovagal syncopes. MATERIAL AND METHODS: The trial included 9 patients with recurrent vasovagal syncopes confirmed at bicycle exercise tests. The patients wore long medical stockings (Sigvaris, Ganzoni & Cie AG, compression of class II). The textile was tailored individually in all the patients. The effect of wearing stockings was tested at bicycle exercise (two tests before wearing to the syncope, one test 1-3 days after the second test upon 1 hour of wearing the stockings). RESULTS: None of the bicycle exercise tests done in the stockings was accompanied with syncopes. None of the patients experienced discomfort while putting on, wearing the stockings or performing the exercise. CONCLUSION: Good therapeutic effects and tolerance were registered when wearing therapeutic textile.