Adverse health effects of PCBs on fine motor performance - Analysis of a neurophysiological pathway in the HELPcB surveillance program.

Since research literature indicates neurotoxic health effects of polychlorinated biphenyls (PCBs), it is necessary to identify by which mechanism PCBs might affect the human central nervous system and human behavior. In the present study, a neurophysiological pathway is assumed to explain the negative association of PCB exposure and performance in fine motor tasks mediated by the level of the dopamine (DA) metabolite homovanillic acid (HVA). A total of 113 occupationally PCB exposed workers and their relatives from an occupational health monitoring program were examined (89.4 % men). PCBs were analyzed in plasma via human biomonitoring and HVA was assessed in urine. The motor performance series was used to measure two dimensions of fine motor skills with 5 subgroups (accuracy: steadiness, line tracking accuracy; speed: line tracking speed, aiming, tapping). The direct effects of PCBs on fine motor performance and the indirect effects of PCBs on fine motor performance via DA metabolite HVA were tested with multiple regressions. We found significant effects for the accuracy dimension, namely a negative direct effect of PCBs on line tracking accuracy mediated by HVA. Further, an indirect effect could be found for PCBs with steadiness accuracy through HVA. There were no significant effects related to fine motor performances in the speed dimension. These results provide first indications for an underlying neurochemical pathomechanism involving the dopamine system of PCB-related deterioration of fine motor performance regarding accuracy.

The Assessment of Psychosocial Work Conditions and Their Relationship to Well-Being: A Multi-Study Report.

The aim of this multi-study report is to present a questionnaire that enables researchers and practitioners to assess and evaluate psychosocial risks related to well-being. In Study 1, we conducted a cross-sectional online-survey in 15 German companies from 2016 to 2017 to verify factor- and criterion-related validity. Data consisted of 1151 employee self-ratings. Exploratory and confirmatory factor analyses resulted in an eight-factor structure (CFI = 0.902, RMSEA = 0.058, and SRMR = 0.070). All scales held to excellent internal consistency values (α = 0.65-0.90) and were related significantly to well-being (r = 0.17-0.35, p < 0.001). A second, longitudinal study in 2018 showed satisfying convergent and discriminant validity (N = 293) to scales from KFZA and COPSOQ. Test-retest reliability (N = 73; α = 0.65-0.88, p < 0.05) was also good. The instrument provides incremental validity above existing instruments since it explains additional variance in well-being.