Detalhe da pesquisa
1.
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
Cell
; 141(7): 1146-58, 2010 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20541250
2.
Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-ßCTF (C99).
J Neurosci
; 39(27): 5255-5268, 2019 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31043483
3.
Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice.
Hum Mol Genet
; 26(5): 843-859, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28062666
4.
Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.
J Neurochem
; 137(2): 253-65, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26756888
5.
Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.
J Neurosci
; 34(28): 9222-34, 2014 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25009256
6.
Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits.
Brain
; 137(Pt 12): 3300-18, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25270989
7.
Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons.
J Neurosci
; 32(25): 8501-8, 2012 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22723690
8.
The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space.
J Biol Chem
; 287(51): 43108-15, 2012 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23129776
9.
G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain.
Neurobiol Dis
; 54: 475-85, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23396011
10.
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification.
Eur J Neurosci
; 37(12): 1949-61, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23773064
11.
Autophagy is a novel pathway for neurofilament protein degradation in vivo.
Autophagy
; 19(4): 1277-1292, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36131358
12.
Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain.
J Neurochem
; 121(4): 649-61, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22372857
13.
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.
Brain
; 134(Pt 1): 258-77, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21186265
14.
Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons.
J Neurosci
; 29(36): 11316-29, 2009 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19741138
15.
The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models.
Neuroimage
; 51(3): 1098-105, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20226865
16.
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
J Cell Biol
; 171(1): 87-98, 2005 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16203860
17.
ß2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7.
J Mol Biol
; 432(8): 2633-2650, 2020 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105735
18.
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice.
J Neurosci
; 28(7): 1682-7, 2008 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18272688
19.
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.
J Neurosci
; 28(27): 6926-37, 2008 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-18596167
20.
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
J Neurosci
; 28(48): 12798-807, 2008 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19036972