Detalhe da pesquisa
1.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.
Nature
; 586(7827): 120-126, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32968282
2.
A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease.
Blood
; 140(19): 2053-2062, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35576529
3.
Bidirectional transport of amino acids regulates mTOR and autophagy.
Cell
; 136(3): 521-34, 2009 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19203585
4.
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency.
N Engl J Med
; 381(10): 933-944, 2019 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31483964
5.
Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.
Blood Cells Mol Dis
; 95: 102660, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35366607
6.
The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency.
Br J Haematol
; 192(6): 1092-1096, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32463523
7.
AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes.
Haematologica
; 106(1): 238-249, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31974203
8.
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Blood
; 130(11): 1347-1356, 2017 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28760888
9.
Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy.
Blood
; 137(21): 2997-3001, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33690814
10.
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.
Proc Natl Acad Sci U S A
; 112(29): 9088-93, 2015 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26150517
11.
Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.
Mol Ther
; 24(7): 1187-98, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27138040
12.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22922757
13.
Structure-Based Design of AG-946, a Pyruvate Kinase Activator.
ChemMedChem
; 19(5): e202300559, 2024 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38109501
14.
The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.
Nat Cell Biol
; 8(1): 78-83, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16327780
15.
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ß-thalassemia mouse model.
J Clin Invest
; 131(10)2021 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822774
16.
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health.
Cell Metab
; 32(5): 751-766.e11, 2020 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33147485
17.
Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 8(2): 246-259, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30091852
18.
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Cell Rep
; 29(11): 3394-3404.e9, 2019 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31825824
19.
Selective kinase inhibition by exploiting differential pathway sensitivity.
Chem Biol
; 13(4): 399-407, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16632252
20.
Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex.
Mol Cell Biol
; 24(4): 1721-35, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14749387