[Aerospace toxicology: basic stages of formation and prospects of development]. / Aviatsionno-kosmicheskaia toksikologiia, osnovnye étapy stanovleniia i perspektivy razvitiia.

The review shows the basic stages of development of aerospace toxicology. It traces the way of forming this research direction from its origin to the present day. Study methods are being improved as practical tasks are becoming more intricate. The names of the Institute's employees who take an active part in the development of this problem and the advances made are enlisted. The results of researches are summed up and further trends are outlined.

[Adaptation to anthropogenic chemical compounds in human applied ecology]. / Nekotorye aspekty adaptatsii k antropogennym khimicheskim soedineniiam v prikladnoi ékologii cheloveka.

The literature data pointing to the fact that man can actively adapt to the effect of chemical substances at doses not exceeding hygienic norms are presented. However using some medical measures it is possible to increase to some extent the body resistance to the effect of chemical impurities of the environment and thus delaying for some time the development of disadaptation disorders induced by these impurities.

[Various characteristics of the action of chemical substances on general adaptability of the body]. / O nekotorykh osobennostiakh vliianiia khimicheskikh soedinenii na obshchuiu adaptosposobnost' organizma.

The article presents a summation of medical literature data and the author's personal studies to the effect that human organism's real adaptation to chemical compounds' action can exist only within standardized limits. Deadapting and disadapting chemical actions have been studied, and it was shown that the peculiarities of their action on the organism's adaptability determine the nature of the total biological response in case with complex chemical and other actions.

[The questions of the combined action on the body of industrial chemical compounds and ionizing radiations]. / Nekotorye voprosy sochetannogo deistviia na organizm promyshlennykh khimicheskikh soedinenii s ioniziruiushchimi izlucheniiami.

Proceeding from the analysis of literature data on the problem of the combined body effect of chemical industrial compounds, a methodological approach to the problem has been developed in order to regulate hygienically the concentration of industrial poisons in the work zone air under the combined effect of ionizing radiation and industrial chemical compounds.

[Combined action on the body of a mixture of the volatile products of lubricating oil thermal oxidative breakdown and of hypoxic hypoxia]. / O kombinirovannom deistvii na organizm smesi letuchikh produktov termookislitel'nogo razlozheniia smazochnogo masla i gipoksicheskoi gipoksii.

The experiments on white male mice have shown that the combined effect of different concentrations of mixtures of volatile products of thermooxidative decomposition of the lubricating oil 36/IKUA and hypoxia at altitudes 5,000; 7,000 and 8,000 m depends on the intensity of the combined factors. It is indicated that maximally allowable concentrations of the above mixtures in the space cabin atmosphere should be determined, taking into consideration the level of hypoxia.

[Short-term action of high carbon monoxide concentrations on the psychophysiological functions of a human operator]. / Issledovanie kratkovremennogo vozdeistviia vysokikh kontsentratsii okisi ugleroda na nekotorye psikhofiziologicheskie funktsii cheloveka-operatora.

Experiments on volunteers, aged 26-40, demonstrated that a 10-minute exposure to carbon monoxide at a concentration of 900 +/- 20 mg/m3 caused a significant decline of the quality of their operator's function. The task they performed was a two-dimensional compensatory tracking task combined with mental arithmetic. Some of the test subjects showed symptoms of mild CO intoxication which preceded disorders in their work and were accompanied by an increase of HbCO to 10 +/- 0.57%. Such an exposure to CO should be regarded as hazardous since it may increase the probability of erroneous actions particularly, of the flying personnel.

[Evaluation of adaptation of animals to hypoxic hypoxia by the multiple regression method]. / Otsenka adaptatsii zhivotnykh k gipoksicneskoi gipoksii s pomoshch'iu metoda mnozhestvennoi regressii.

White mice were exposed to hypoxic hypoxia during 30 days. In the study a correlation between the altitude ceiling and various physiological parameters (body weight, body temperature variations in response to a cold stress (5 degrees C), hemoglobin content, coefficients of adaptive oxygen consumption determined as the ratio of oxygen consumption at 6000 m to that at sea level (K1) and the ratio of oxygen consumption in hypoxic environment to that in a normoxic atmosphere (K2) was established. The data obtained allow the conclusion that the multiple regression method can be used for measuring objectively the tension of regulatory systems and for discriminating stages of animal adaptation to hypoxic hypoxia.

[Combined action on the body of carbon monoxide and normobaric hyperoxia]. / Kombinirovannoe deistvie na organizm okisi ugleroda i normobaricheskoi giperoksii.

Thirty-day experiments on white male rats were carried out to determine the combined effect of carbon monoxide and hyperoxic atmosphere on the animal body. The two factors showed an antagonistic biological effect, the influence of hyperoxic atmosphere prevailing over that of carbon monoxide. It is suggested that during a combined exposure of animals to the two factors maximally allowable concentrations of each can be used without any corrections.

[Effect of hyperoxia and hypokinesia on the formation and excretion of gaseous metabolic products in rats]. / Vliianie giperoksii i gipokinezii na obrazovanie i vydelenie gazoobraznykh produktov zhiznedeiatel'nosti u krys

It has been shown experimentally that a 30-day exposure of white rats to hypokinesia and moderate hyperoxia decreases elimination of ammonia and increases the formation and release into an enclosed atmosphere of carbon monoxide, aldehydes and ketones. The level of metabolism of prophyrin and nitrogen containing compounds as well as of fats and carbohydrates is higher during a combined effect of hypokinesia and moderate hyperoxia than during their separate influences.