Detalhe da pesquisa
1.
Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease.
Am J Physiol Renal Physiol
; 326(5): F839-F854, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38450434
2.
Nicotine aerosols diminish airway CFTR function and mucociliary clearance.
Am J Physiol Lung Cell Mol Physiol
; 324(5): L557-L570, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36852921
3.
Airway remodeling in ferrets with cigarette smoke-induced COPD using µCT imaging.
Am J Physiol Lung Cell Mol Physiol
; 319(1): L11-L20, 2020 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32374671
4.
Excess mucus viscosity and airway dehydration impact COPD airway clearance.
Eur Respir J
; 55(1)2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31672759
5.
A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein.
Mol Cell
; 44(1): 108-19, 2011 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21981922
6.
Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant.
Nat Commun
; 15(1): 3140, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38605083
7.
Alcohol-Induced Mucociliary Dysfunction: Role of Defective CFTR Channel Function.
bioRxiv
; 2023 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37502889
8.
Spatiotemporal immune atlas of the first clinical-grade, gene-edited pig-to-human kidney xenotransplant.
Res Sq
; 2023 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711785
9.
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
J Med Chem
; 66(7): 4888-4909, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36940470
10.
Resident macrophage subpopulations occupy distinct microenvironments in the kidney.
JCI Insight
; 7(20)2022 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36066976
11.
Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma.
Exp Eye Res
; 93(3): 256-64, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21376717
12.
Identification of novel pyrrolopyrazoles as protein kinase C ß II inhibitors.
Bioorg Med Chem Lett
; 21(1): 584-7, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21084194
13.
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
J Med Chem
; 64(1): 644-661, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356246
14.
Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models.
Exp Eye Res
; 89(5): 608-17, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19445930
15.
Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
Bioorg Med Chem Lett
; 19(8): 2099-102, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19327989
16.
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.
J Med Chem
; 60(7): 3002-3019, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28287730
17.
Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
J Med Chem
; 59(5): 2005-24, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26756222
18.
Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressure.
J Med Chem
; 58(6): 2821-33, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728019
19.
Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model.
Eur J Pharmacol
; 627(1-3): 16-25, 2010 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19850035
20.
In vivo evaluation of 11beta-hydroxysteroid dehydrogenase activity in the rabbit eye.
J Ocul Pharmacol Ther
; 25(3): 215-22, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19456256