Detalhe da pesquisa
1.
GPR68 Senses Flow and Is Essential for Vascular Physiology.
Cell
; 173(3): 762-775.e16, 2018 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29677517
2.
Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.
Bioorg Med Chem Lett
; 29(3): 503-508, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30594433
3.
Small-molecule inducer of ß cell proliferation identified by high-throughput screening.
J Am Chem Soc
; 135(5): 1669-72, 2013 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23330637
4.
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency.
Proc Natl Acad Sci U S A
; 107(8): 3552-7, 2010 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20133595
5.
Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids.
Proc Natl Acad Sci U S A
; 106(11): 4337-42, 2009 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19246393
6.
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.
Nat Med
; 9(2): 213-9, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12524534
7.
Identification of a small molecule that stimulates human ß-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.
PLoS One
; 15(3): e0224344, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32176701
8.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 9(3): 395-410, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31823525
9.
A Dual Inhibitor of DYRK1A and GSK3ß for ß-Cell Proliferation: Aminopyrazine Derivative GNF4877.
ChemMedChem
; 15(16): 1562-1570, 2020 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32613743
10.
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
J Med Chem
; 63(8): 3868-3880, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31940200
11.
Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
J Med Chem
; 63(6): 2958-2973, 2020 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32077280
12.
Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents.
Hepatol Commun
; 3(8): 1085-1097, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31388629
13.
The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.
Mol Cell Biol
; 23(6): 2182-91, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12612088
14.
Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
J Med Chem
; 60(24): 9960-9973, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29148806
15.
Pancreas-Specific Delivery of ß-Cell Proliferating Small Molecules.
ChemMedChem
; 11(11): 1129-32, 2016 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27095073
16.
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
J Med Chem
; 48(17): 5419-22, 2005 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16107141
17.
Inhibition of DYRK1A and GSK3B induces human ß-cell proliferation.
Nat Commun
; 6: 8372, 2015 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26496802
18.
Liver X receptor modulators: a review of recently patented compounds (2009 - 2012).
Expert Opin Ther Pat
; 23(10): 1317-35, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23826715
19.
Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth.
Oncotarget
; 4(12): 2502-11, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24318446
20.
A laparoscopic knot-tying device for minimally invasive cardiac surgery.
Eur J Cardiothorac Surg
; 37(3): 626-30, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854658