Detalhe da pesquisa
1.
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy.
Med Res Rev
; 44(2): 686-706, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-37983866
2.
Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management.
Phytother Res
; 2024 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38522945
3.
Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.
Bioorg Med Chem
; 45: 116311, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34304133
4.
FCX-146, a potent allosteric inhibitor of Akt kinase in cancer cells: Lead optimization of the second-generation arylidene indanone scaffold.
Biotechnol Appl Biochem
; 68(1): 82-91, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32067263
5.
Pyrazolopyridine-based kinase inhibitors for anti-cancer targeted therapy.
RSC Med Chem
; 15(5): 1452-1470, 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38784451
6.
Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules.
RSC Med Chem
; 15(2): 399-415, 2024 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38389874
7.
An innovative approach for predicting pandemic hotspots in complex wastewater networks using graph theory coupled with fuzzy logic.
Stoch Environ Res Risk Assess
; : 1-18, 2023 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37362844
8.
FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms.
RSC Med Chem
; 13(7): 798-816, 2022 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35923716
9.
Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
J Med Chem
; 65(2): 1536-1551, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35081714
10.
Pyrazoloadenine Inhibitors of the RET Lung Cancer Oncoprotein Discovered by a Fragment Optimization Approach.
ChemMedChem
; 16(10): 1605-1608, 2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33559353
11.
Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development.
J Med Chem
; 64(16): 11747-11773, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34402300
12.
Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases.
Sci Rep
; 11(1): 16103, 2021 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34373541
13.
Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.
Eur J Med Chem
; 225: 113776, 2021 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34479037
14.
Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression.
Eur J Med Chem
; 203: 112589, 2020 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32717530
15.
The Exploration of Chirality for Improved Druggability within the Human Kinome.
J Med Chem
; 63(2): 441-469, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31550151
16.
Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation.
Eur J Med Chem
; 206: 112691, 2020 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32823007
17.
Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology.
J Med Chem
; 63(9): 4506-4516, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32298114
18.
Structural Characterization of the Aurora Kinase B "DFG-flip" Using Metadynamics.
AAPS J
; 22(1): 14, 2019 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31853739
19.
Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
J Med Chem
; 62(4): 1731-1760, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30188734
20.
Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts.
Chem Commun (Camb)
; 54(92): 12954-12957, 2018 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30375586