1.
Chem Commun (Camb)
; 59(83): 12487-12490, 2023 Oct 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37786313
RESUMO
Supramolecular carrier-mediated chemotherapy is a highly attractive strategy for targeted drug delivery. In this study, four novel biotin-linked calix[4]arenes BPCA1-BPCA4 have been rationally designed to construct nano-complex with doxorubicin. The in vitro and in vivo assessments reveal that BPCA4-DOX with excellent stability are capable of affording significantly superior anti-tumor activity and lower side effects.