Detalhe da pesquisa
1.
Genome-Wide Small Interfering RNA Screening Reveals a Role for Cullin3-Really Interesting New Gene Ligase Signaling in Heterologous Sensitization of Adenylyl Cyclase.
J Pharmacol Exp Ther
; 372(3): 267-276, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31857349
2.
Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3.
Brain
; 139(11): 2891-2908, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27645800
3.
Narrow-spectrum inhibitors of Campylobacter jejuni flagellar expression and growth.
Antimicrob Agents Chemother
; 59(7): 3880-6, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25870073
4.
Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice.
Proc Natl Acad Sci U S A
; 109(9): 3469-74, 2012 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22331877
5.
Application of a high-throughput fluorescent acetyltransferase assay to identify inhibitors of homocitrate synthase.
Anal Biochem
; 410(1): 133-40, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21073853
6.
Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.
Mol Pharmacol
; 78(3): 524-33, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20571077
7.
Identification of inhibitors of yellow fever virus replication using a replicon-based high-throughput assay.
Antimicrob Agents Chemother
; 53(10): 4103-14, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19651907
8.
High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay.
J Biomol Screen
; 14(2): 161-72, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19196702
9.
Development and Implementation of an HTS-Compatible Assay for the Discovery of Selective Small-Molecule Ligands for Pre-microRNAs.
SLAS Discov
; 23(1): 47-54, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28686847
10.
From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.
JCI Insight
; 3(14)2018 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046004
11.
Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer.
Clin Cancer Res
; 24(24): 6509-6522, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30185422
12.
Identification of a platyhelminth neuropeptide receptor.
Int J Parasitol
; 37(7): 725-33, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17362965
13.
Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis.
ACS Chem Biol
; 11(11): 3084-3092, 2016 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27622287
14.
The combined use of alphavirus replicons and pseudoinfectious particles for the discovery of antivirals derived from natural products.
J Biomol Screen
; 20(5): 673-80, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25550354
15.
Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries.
Chem Biol Drug Des
; 86(6): 1331-8, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26147927
16.
Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts.
ACS Med Chem Lett
; 6(8): 877-81, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288688
17.
Inhibitors of TonB function identified by a high-throughput screen for inhibitors of iron acquisition in uropathogenic Escherichia coli CFT073.
mBio
; 5(2): e01089-13, 2014 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24570372
18.
The role of HTS in drug discovery at the University of Michigan.
Comb Chem High Throughput Screen
; 17(3): 210-30, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24409957
19.
Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast.
Int J Parasitol Drugs Drug Resist
; 3: 1-7, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24533288
20.
An inhibitor of the protein kinases TBK1 and IKK-É improves obesity-related metabolic dysfunctions in mice.
Nat Med
; 19(3): 313-21, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23396211