Detalhe da pesquisa
1.
Building a three-dimensional model of CYP2C9 inhibition using the Autocorrelator: an autonomous model generator.
J Chem Inf Model
; 52(5): 1328-36, 2012 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22509999
2.
Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity.
J Med Chem
; 64(17): 12670-12679, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34459599
3.
CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia.
J Med Chem
; 64(4): 1835-1843, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33591756
4.
Discovery of the c-Jun N-Terminal Kinase Inhibitor CC-90001.
J Med Chem
; 64(24): 18193-18208, 2021 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34894681
5.
Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005.
J Med Chem
; 64(16): 11886-11903, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34355886
6.
Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons.
ACS Chem Biol
; 15(12): 3149-3158, 2020 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33206504
7.
Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma.
J Med Chem
; 63(13): 6648-6676, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32130004
8.
5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 19(2): 451-8, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19054673
9.
5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 19(21): 6047-52, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19796938
10.
Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 19(22): 6404-12, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19818610
11.
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.
J Med Chem
; 62(9): 4401-4410, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30998356
12.
ATLAS--a high-throughput affinity-based screening technology for soluble proteins: technology application using p38 MAP kinase.
Assay Drug Dev Technol
; 6(1): 55-68, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18336086
13.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Bioorg Med Chem Lett
; 18(4): 1413-8, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242088
14.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.
Bioorg Med Chem Lett
; 18(4): 1419-24, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18226901
15.
Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 18(18): 5002-5, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18722768
16.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.
Bioorg Med Chem Lett
; 18(20): 5635-9, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18796353
17.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
Bioorg Med Chem Lett
; 18(11): 3421-6, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18442904
18.
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 18(12): 3616-21, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18487044
19.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Bioorg Med Chem Lett
; 18(11): 3446-55, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18457949
20.
Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett
; 18(14): 4181-5, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18554907