Detalhe da pesquisa
1.
Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models.
Circulation
; 147(3): 242-253, 2023 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36314243
2.
Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease.
Hum Mol Genet
; 31(21): 3597-3612, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35147173
3.
Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM.
Nature
; 560(7717): 263-267, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30089917
4.
Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis.
J Cell Sci
; 133(14)2020 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32576663
5.
Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes.
Arterioscler Thromb Vasc Biol
; 41(4): 1309-1318, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33626909
6.
Antisense oligonucleotide-mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice.
J Lipid Res
; 62: 100101, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34371033
7.
Reversal of hypertriglyceridemia in diabetic BTBR ob/ob mice does not prevent nephropathy.
Lab Invest
; 101(7): 935-941, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33911188
8.
Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle.
Nucleic Acids Res
; 47(12): 6029-6044, 2019 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31127296
9.
Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.
PLoS Genet
; 14(10): e1007732, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30372444
10.
Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides.
N Engl J Med
; 377(3): 222-232, 2017 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28538111
11.
Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor.
Arterioscler Thromb Vasc Biol
; 39(9): 1747-1761, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167565
12.
ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors.
Arterioscler Thromb Vasc Biol
; 39(10): 2145-2156, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31390883
13.
Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.
Arterioscler Thromb Vasc Biol
; 38(1): 218-231, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29074585
14.
Is mitochondrial gene expression coordinated or stochastic?
Biochem Soc Trans
; 46(5): 1239-1246, 2018 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30301847
15.
Amelioration of diet-induced steatohepatitis in mice following combined therapy with ASO-Fsp27 and fenofibrate.
J Lipid Res
; 58(11): 2127-2138, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28874443
16.
Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance.
J Lipid Res
; 58(1): 81-91, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27884961
17.
The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.
J Lipid Res
; 58(2): 420-432, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27941027
18.
Targeting IκB kinase ß in Adipocyte Lineage Cells for Treatment of Obesity and Metabolic Dysfunctions.
Stem Cells
; 34(7): 1883-95, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26991836
19.
TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.
J Hepatol
; 62(2): 371-9, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25281858
20.
Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans.
Circ Res
; 112(11): 1479-90, 2013 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23542898