Detalhe da pesquisa
1.
Intra-islet glucagon confers ß-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon.
J Biol Chem
; 298(2): 101484, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896391
2.
The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 engages the glucagon-like peptide-1 incretin hormone axis to lower levels of blood glucose in db/db mice.
Diabetes Obes Metab
; 24(7): 1255-1266, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293666
3.
"A-kinase" regulator runs amok to provide a paradigm shift in cAMP signaling.
J Biol Chem
; 294(7): 2247-2248, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30765510
4.
Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.
J Biol Chem
; 294(10): 3514-3531, 2019 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622136
5.
Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation.
Rev Endocr Metab Disord
; 21(4): 431-447, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32851581
6.
Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 ß-Cells.
J Biol Chem
; 292(6): 2266-2277, 2017 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28003364
7.
Interplay between ER Ca2+ Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca2+ Entry.
Int J Mol Sci
; 19(5)2018 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29783744
8.
Correction: Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.
J Biol Chem
; 294(22): 8714, 2019 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31152095
9.
New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice.
Biochim Biophys Acta
; 1842(12 Pt B): 2593-600, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980705
10.
Isoform-specific antagonists of exchange proteins directly activated by cAMP.
Proc Natl Acad Sci U S A
; 109(45): 18613-8, 2012 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23091014
11.
Resveratrol Interferes with Fura-2 Intracellular Calcium Measurements.
J Fluoresc
; 24(2): 279-84, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24151033
12.
Excess pancreatic elastase alters acinar-ß cell communication by impairing the mechano-signaling and the PAR2 pathways.
Cell Metab
; 35(7): 1242-1260.e9, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37339634
13.
Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in ß-cells of phospholipase C-ε knockout mice.
J Physiol
; 588(Pt 24): 4871-89, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21041529
14.
PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.
Am J Physiol Endocrinol Metab
; 298(3): E622-33, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20009023
15.
Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells.
J Physiol
; 586(5): 1307-19, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18202100
16.
Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells.
Biochem Biophys Res Commun
; 368(3): 614-9, 2008 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18243136
17.
Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets.
Diabetes
; 67(10): 1999-2011, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29986926
18.
α7 Nicotinic Acetylcholine Receptor Regulates the Function and Viability of L Cells.
Endocrinology
; 159(9): 3132-3142, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29992246
19.
Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.
Sci Rep
; 8(1): 3749, 2018 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29491394
20.
Publisher Correction: Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.
Sci Rep
; 8(1): 6192, 2018 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29654321