Detalhe da pesquisa
1.
Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis.
PLoS Med
; 15(6): e1002579, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29894518
2.
Spiroindolone KAE609 for falciparum and vivax malaria.
N Engl J Med
; 371(5): 403-10, 2014 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25075833
3.
Open-label, single-dose, parallel-group study in healthy volunteers to determine the drug-drug interaction potential between KAE609 (cipargamin) and piperaquine.
Antimicrob Agents Chemother
; 59(6): 3493-500, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25845867
4.
Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®).
Malar J
; 14: 157, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25886021
5.
A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel antimalarial Spiroindolone KAE609 (Cipargamin) to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers.
Antimicrob Agents Chemother
; 58(10): 6209-14, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25114127
6.
Evaluation of two novel tablet formulations of artemether-lumefantrine (Coartem) for bioequivalence in a randomized, open-label, two-period study.
Malar J
; 12: 312, 2013 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24010572
7.
Pharmacokinetic and pharmacodynamic characteristics of a new pediatric formulation of artemether-lumefantrine in African children with uncomplicated Plasmodium falciparum malaria.
Antimicrob Agents Chemother
; 55(9): 3994-9, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21670177
8.
Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges.
Malar J
; 10: 369, 2011 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22176931
9.
The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria.
Trop Med Int Health
; 15(4): 434-41, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20180933
10.
Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects.
Malar J
; 9: 253, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20815879
11.
A Pooled Analysis of Three Randomized Phase I/IIa Clinical Trials Confirms Absence of a Clinically Relevant Effect on the QTc Interval by Umibecestat.
Clin Transl Sci
; 13(6): 1316-1326, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32583957
12.
Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial.
Lancet
; 372(9652): 1819-27, 2008 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18926569
13.
Similar rivastigmine pharmacokinetics and pharmacodynamics in Japanese and white healthy participants following the application of novel rivastigmine patch.
J Clin Pharmacol
; 49(4): 430-43, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19246725
14.
Understanding the pharmacokinetics of Coartem.
Malar J
; 8 Suppl 1: S4, 2009 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19818171
15.
Treatment of acute uncomplicated falciparum malaria with artemether-lumefantrine in nonimmune populations: a safety, efficacy, and pharmacokinetic study.
Am J Trop Med Hyg
; 78(2): 241-7, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18256423
16.
Steady-state pharmacokinetics of rivastigmine in patients with mild to moderate Alzheimer's disease not affected by co-administration of memantine: an open-label, crossover, single-centre study.
Clin Drug Investig
; 28(6): 361-74, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18479178
17.
Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: relative effects of body site application.
J Clin Pharmacol
; 47(4): 471-8, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17389556
18.
Pharmacokinetic Modeling to Simulate the Concentration-Time Profiles After Dermal Application of Rivastigmine Patch.
J Pharm Sci
; 105(7): 2213-21, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27212635
19.
Effects of Renal Impairment on Steady-State Plasma Concentrations of Rivastigmine: A Population Pharmacokinetic Analysis of Capsule and Patch Formulations in Patients with Alzheimer's Disease.
Drugs Aging
; 33(10): 725-736, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27681702
20.
Comparison of the cardiac effects of the antimalarials co-artemether and halofantrine in healthy participants.
Am J Trop Med Hyg
; 66(3): 293-8, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12139223