Detalhe da pesquisa
1.
Challenges in Discovering Drugs That Target the Protein-Protein Interactions of Disordered Proteins.
Int J Mol Sci
; 23(3)2022 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35163473
2.
HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)*.
Chembiochem
; 21(23): 3371-3376, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32672888
3.
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
Biochim Biophys Acta Mol Basis Dis
; 1863(1): 310-323, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671864
4.
Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.
Biochim Biophys Acta
; 1852(1): 83-91, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25445539
5.
Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates.
Bioorg Med Chem Lett
; 26(1): 154-9, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26611919
6.
Structure-Based Development of an Affinity Probe for Sirtuinâ 2.
Angew Chem Int Ed Engl
; 55(6): 2252-6, 2016 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26748890
7.
Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25.
Biochim Biophys Acta
; 1842(4): 547-57, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24463170
8.
Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP.
Cells
; 13(4)2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38391951
9.
Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology.
Cells
; 11(19)2022 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36230985
10.
TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.
J Biol Chem
; 285(23): 17896-906, 2010 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20308065
11.
Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein.
Cells
; 10(11)2021 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34831132
12.
Co-Transmission of Alpha-Synuclein and TPPP/p25 Inhibits Their Proteolytic Degradation in Human Cell Models.
Front Mol Biosci
; 8: 666026, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34084775
13.
Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation.
Glia
; 58(2): 157-68, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19606501
14.
Microtubule-Associated Proteins with Regulatory Functions by Day and Pathological Potency at Night.
Cells
; 9(2)2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32033023
15.
Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.
Biochim Biophys Acta Mol Cell Res
; 1866(12): 118556, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31505170
16.
New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2.
Philos Trans R Soc Lond B Biol Sci
; 373(1748)2018 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29685963
17.
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).
J Med Chem
; 61(2): 482-491, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28379698
18.
Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency.
Sci Rep
; 7(1): 17070, 2017 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29213065
19.
Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies.
FEBS Lett
; 580(25): 5807-14, 2006 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17027006
20.
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.
J Med Chem
; 59(4): 1599-612, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26696402