RESUMO
We present a novel formalism to describe the in vacuo conversion between polarization states of propagating radiation, also known as generalized Faraday effect (GFE), in a cosmological context. Thinking of GFE as a potential tracer of new, isotropy- and/or parity-violating physics, we apply our formalism to the cosmic microwave background (CMB) polarized anisotropy power spectra, providing a simple framework to easily compute their observed modifications. In so doing, we re-interpret previously known results, namely, the in vacuo rotation of the linear polarization plane of CMB photons (or cosmic birefringence) but also point out that GFE could lead to the partial conversion of linear into circular polarization. We notice that GFE can be seen as an effect of light propagating in an anisotropic and/or chiral medium (a "dark crystal") and recast its parameters as the components of an effective "cosmic susceptibility tensor." For a wave number-independent susceptibility tensor, this allows us to set an observational bound on a GFE-induced CMB circularly polarized power spectrum, or VV, at C_{â}^{VV}<2×10^{-5} µK^{2} (95% C.L.), at its peak â≃370, which is some 3 orders of magnitude better than presently available direct VV measurements. We argue that, unless dramatic technological improvements will arise in direct V-modes measurements, cosmic variance-limited linear polarization surveys expected within this decade should provide, as a byproduct, superior bounds on GFE-induced circular polarization of the CMB.
RESUMO
End-stage kidney disease (ESKD) exposes patients to progressive physical deconditioning involving the respiratory muscles. The aim of this pilot randomized controlled trial was to determine the feasibility and effectiveness of low-intensity respiratory muscle training (RMT) learned at the hospital and performed at home. A group of ESKD patients (n = 22) were randomized into RMT or usual care (control group, CON) in a 1:1 ratio. The respiratory training was performed at home with an inspiratory-expiratory system for a total of 5 min of breathing exercises in a precise rhythm (8 breaths per minute) interspersed with 1 min of rest, two times per day on nondialysis days for a total of 4 weeks, with the air resistance progressively increasing. Outcome measures were carried out every 4 weeks for 3 consecutive months, with the training executed from the 5th to the 8th week. Primary outcomes were maximal inspiratory and expiratory pressure (MIP, MEP), while secondary outcomes were lung capacity (FEV1, FVC, MVV). Nineteen patients without baseline between-group differences completed the trial (T: n = 10; Age: 63 ± 10; Males: n = 12). Both MIP and MEP significantly improved at the end of training in the T group only, with a significant difference of MEP of 23 cmH2O in favor of the RMT group (p = 0.008). No significant variations were obtained for FVC, FEV1 or MVV in either group, but there was a greater decreasing trend over time for the CON group, particularly for FVC (t = -2.00; p = 0.046). Low-fatiguing home-based RMT, with a simple device involving both inspiratory and expiratory muscles, may significantly increase respiratory muscle strength.