Detalhe da pesquisa
1.
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.
Proc Natl Acad Sci U S A
; 116(4): 1414-1419, 2019 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617067
2.
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.
Proc Natl Acad Sci U S A
; 109(21): 8298-303, 2012 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22566611
3.
Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum.
RSC Chem Biol
; 5(1): 19-29, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38179191
4.
Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis.
ACS Infect Dis
; 9(2): 221-238, 2023 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36606559
5.
Targeting the Ubiquinol-Reduction (Qi) Site of the Mitochondrial Cytochrome bc1 Complex for the Development of Next Generation Quinolone Antimalarials.
Biology (Basel)
; 11(8)2022 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35892964
6.
Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205.
ACS Med Chem Lett
; 12(7): 1077-1085, 2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267877
7.
Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?
ACS Infect Dis
; 7(6): 1317-1331, 2021 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33352056
8.
Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis.
ACS Med Chem Lett
; 12(9): 1421-1426, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34527179
9.
Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) Inhibitors with Improved Drug-like Properties.
ACS Med Chem Lett
; 9(12): 1205-1210, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613327
10.
Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.
J Med Chem
; 60(9): 3703-3726, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28304162
11.
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
J Med Chem
; 55(5): 1831-43, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22364416
12.
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
J Med Chem
; 55(5): 1844-57, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22364417
13.
Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.
J Med Chem
; 53(2): 633-40, 2010 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19957999