RESUMO
Neuroleptic malignant syndrome (NMS) is a life-threatening neurologic emergency that may be caused by neuroleptic agents of any class. The association with hyperosmolar hyperglycemic state (HHS) is rare and carries a grave prognosis. We describe the case of a 25-year-old male patient with haloperidol-induced NMS complicated by HHS that culminated in the patient's death despite all treatment efforts. Physicians caring for diabetic psychiatric patients who are treated with neuroleptic agents should be aware of this association that may be prevented by tight glycemic control.
Assuntos
Antipsicóticos/efeitos adversos , Haloperidol/efeitos adversos , Hiperglicemia/complicações , Síndrome Maligna Neuroléptica/complicações , Síndrome Maligna Neuroléptica/etiologia , Adulto , Evolução Fatal , Humanos , Masculino , Hipertermia Maligna/complicações , Hipertermia Maligna/tratamento farmacológico , Síndrome de Munchausen/tratamento farmacológico , Esquizofrenia/tratamento farmacológicoRESUMO
We describe a 17-year-old boy with congenital spherocytosis and iron overload who presented with compartment syndrome of the calf as the initial manifestation of Vibrio vulnificus infection after minor trauma in a contaminated fish pond. The disease was complicated by necrotizing fasciitis requiring above the knee amputation. Childhood diseases associated with iron overload pose an increased risk for complicated V. vulnificus infections.