Detalhe da pesquisa
1.
Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups.
ACS Med Chem Lett
; 13(6): 964-971, 2022 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35707148
2.
Interaction of cholesterol-conjugated ionizable amino lipids with biomembranes: lipid polymorphism, structure-activity relationship, and implications for siRNA delivery.
Langmuir
; 27(15): 9473-83, 2011 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21648950
3.
Ionization behavior of amino lipids for siRNA delivery: determination of ionization constants, SAR, and the impact of lipid pKa on cationic lipid-biomembrane interactions.
Langmuir
; 27(5): 1907-14, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21250743
4.
Difluoroethylamines as an amide isostere in inhibitors of cathepsin K.
Bioorg Med Chem Lett
; 21(3): 920-3, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21232956
5.
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Bioorg Med Chem Lett
; 20(20): 6088-92, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20832306
6.
Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.
J Med Chem
; 50(15): 3427-30, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17608398
7.
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 49(12): 3614-27, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759103
8.
Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.
J Med Chem
; 51(20): 6259-62, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18811140
9.
Cyclopentane-based human NK1 antagonists. Part 1: discovery and initial SAR.
Bioorg Med Chem Lett
; 16(17): 4497-503, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16824752