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Researches on superhydrophobicity have been overwhelming and have shown great advantages in various fields. However, the abrasion resistance of superhydrophobic structures was usually poor, and they were easily damaged by external force or harsh environment, which greatly limited the applications of superhydrophobic surfaces. Much attention has been paid to improving the abrasion resistance of superhydrophobic materials by researchers. In this review, aimed at the advances on improving the abrasion resistance of superhydrophobic surfaces, it was summarized and compared three enhancement strategies including the reasonably design of micro-nano structures, the adoption of adhesives, and the preparation of self-healing surface. Finally, the applications of typical superhydrophobic materials with abrasion resistance were reviewed in various fields. In order to broaden the application fields of superhydrophobic materials, the abarasion resistance should be further improved. Therefore, we proposed the ideas for the future development of superhydrophobic materials with higher abrasion resistance. We hope that this review will provide a new approach to the preparation and development of stable superhydrophobic surfaces with higher abrasion resistance.
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BACKGROUND: With the development of modern medicine, the Traditional Chinese Medicine (TCM) combined with western medicine began to be produced and applied. Scalp acupuncture (SA) as a Chinese medicine based on neurological theory, has a great advantage compared with TCM in the treatment of nervous system diseases. METHOD: In this paper, we analyze the physiological and pathological manifestations of sexual dimorphism (SD) to illustrate the necessity of SD treatment. In addition, we review the factors that can affect SD and analyze in physiological structure, function, and pathological neurons. Diseases (pathological basis, pathological manifestations, and incidence) and factors leading to gender differences, which to analyze the possibility of gender differences in SA. RESULT: Furthermore, we creatively a new insight of SD-SA and provide the complete SD treatment cases on the basis of the existing SA in different kinds of diseases including stroke, migraine, attention deficit hyperactivity disorder (ADHD), and depression. CONCLUSION: In summary, we believe that it is feasible to improve the clinical effectiveness of SA, which is able to promote the development of SA, and then provides an actionable evidence for the promotion of precision medicine in the future.
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Terapia por Acupuntura , Doenças do Sistema Nervoso , Humanos , Couro Cabeludo , Caracteres Sexuais , Fatores SexuaisRESUMO
PURPOSE: To explore the utility of high frequency oscillations (HFO) and long-range temporal correlations (LRTCs) in preoperative assessment of epilepsy. METHODS: MEG ripples were detected in 59 drug-resistant epilepsy patients, comprising 5 with parietal lobe epilepsy (PLE), 21 with frontal lobe epilepsy (FLE), 14 with lateral temporal lobe epilepsy (LTLE), and 19 with mesial temporal lobe epilepsy (MTLE) to identify the epileptogenic zone (EZ). The results were compared with clinical MEG reports and resection area. Subsequently, LRTCs were quantified at the source-level by detrended fluctuation analysis (DFA) and life/waiting -time at 5 bands for 90 cerebral cortex regions. The brain regions with larger DFA exponents and standardized life-waiting biomarkers were compared with the resection results. RESULTS: Compared to MEG sensor-level data, ripple sources were more frequently localized within the resection area. Moreover, source-level analysis revealed a higher proportion of DFA exponents and life-waiting biomarkers with relatively higher rankings, primarily distributed within the resection area (p<0.01). Moreover, these two LRCT indices across five distinct frequency bands correlated with EZ. CONCLUSION: HFO and source-level LRTCs are correlated with EZ. Integrating HFO and LRTCs may be an effective approach for presurgical evaluation of epilepsy.
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Epilepsia Resistente a Medicamentos , Epilepsias Parciais , Magnetoencefalografia , Humanos , Magnetoencefalografia/métodos , Feminino , Adulto , Masculino , Epilepsias Parciais/cirurgia , Epilepsias Parciais/fisiopatologia , Adulto Jovem , Epilepsia Resistente a Medicamentos/cirurgia , Epilepsia Resistente a Medicamentos/fisiopatologia , Adolescente , Pessoa de Meia-Idade , Eletroencefalografia/métodos , Córtex Cerebral/fisiopatologia , Córtex Cerebral/cirurgia , Cuidados Pré-Operatórios/métodos , Ondas Encefálicas/fisiologiaRESUMO
OBJECTIVE: To explore the association between high-frequency oscillations (HFOs) and epilepsy types and to improve the accuracy of source localization. METHODS: Magnetoencephalography (MEG) ripples of 63 drug-resistant epilepsy patients were detected. Ripple rates, distribution, spatial complexity, and the clustering coefficient of ripple channels were used for the preliminary classification of lateral temporal lobe epilepsy (LTLE), mesial temporal lobe epilepsy (MTLE), and nontemporal lobe epilepsy (NTLE), mainly frontal lobe epilepsy (FLE). Furthermore, the seizure site identification was improved using the Tucker LCMV method and source-level betweenness centrality. RESULTS: Ripple rates were significantly higher in MTLE than in LTLE and NTLE (p < 0.05). The LTLE and MTLE were mainly distributed in the temporal lobe, followed by the parietal lobe, occipital lobe, and frontal lobe, whereas MTLE ripples were mainly distributed in the frontal lobe, then parietal lobe and occipital lobe. Nevertheless, the NTLE ripples were primarily in the frontal lobe and partially in the occipital lobe (p < 0.05). Meanwhile, the spatial complexity of NTLE was significantly higher than that of LTLE and MTLE and was lowest in MTLE (p < 0.01). However, an opposite trend was observed for the standardized clustering coefficient compared with spatial complexity (p < 0.01). Finally, the tucker algorithm showed a higher percentage of ripples at the surgical site when the betweenness centrality was added (p < 0.01). CONCLUSION: This study demonstrated that HFO rates, distribution, spatial complexity, and clustering coefficient of ripple channels varied considerably among the three epilepsy types. Additionally, tucker MEG estimation combined with ripple rates based on the source-level functional connectivity is a promising approach for presurgical epilepsy evaluation.
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Epilepsia do Lobo Temporal , Epilepsia , Humanos , Epilepsia do Lobo Temporal/cirurgia , Magnetoencefalografia , Lobo Temporal , Epilepsia/cirurgia , Convulsões , EletroencefalografiaRESUMO
Objective.Cognitive impairment is one of the core symptoms of schizophrenia, with an emphasis on dysfunctional information processing. Sensory gating deficits have consistently been reported in schizophrenia, but the underlying physiological mechanism is not well-understood. We report the discovery and characterization of P50 dynamic brain connections based on microstate analysis.Approach.We identify five main microstates associated with the P50 response and the difference between the first and second click presentation (S1-S2-P50) in first-episode schizophrenia (FESZ) patients, ultra-high-risk individuals (UHR) and healthy controls (HCs). We used the signal segments composed of consecutive time points with the same microstate label to construct brain functional networks.Main results.The microstate with a prefrontal extreme location during the response to the S1 of P50 are statistically different in duration, occurrence and coverage among the FESZ, UHR and HC groups. In addition, a microstate with anterior-posterior orientation was found to be associated with S1-S2-P50 and its coverage was found to differ among the FESZ, UHR and HC groups. Source location of microstates showed that activated brain regions were mainly concentrated in the right temporal lobe. Furthermore, the connectivities between brain regions involved in P50 processing of HC were widely different from those of FESZ and UHR.Significance.Our results indicate that P50 suppression deficits in schizophrenia may be due to both aberrant baseline sensory perception and adaptation to repeated stimulus. Our findings provide new insight into the mechanisms of P50 suppression in the early stage of schizophrenia.
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Esquizofrenia , Encéfalo , Eletroencefalografia/métodos , Potenciais Evocados Auditivos/fisiologia , Humanos , Filtro Sensorial/fisiologiaRESUMO
Carotid artery stenotic plaque segmentation in ultrasound images is a crucial means for the analysis of plaque components and vulnerability. However, segmentation of severe stenotic plaques remains a challenging task because of the heterogeneities of inter-plaques and intra-plaques, and obscure boundaries of plaques. In this paper, we propose an automated HRU-Net transfer learning method for segmenting carotid plaques, using the limited images. The HRU-Net is based on the U-Net encoder−decoder paradigm, and cross-domain knowledge is transferred for plaque segmentation by fine-tuning the pretrained ResNet-50. Moreover, a cropped-blood-vessel image augmentation is customized for the plaque position constraint during training only. Moreover, hybrid atrous convolutions (HACs) are designed to derive diverse long-range dependences for refined plaque segmentation that are used on high-level semantic layers to exploit the implicit discrimination features. The experiments are performed on 115 images; Firstly, the 10-fold cross-validation, using 40 images with severe stenosis plaques, shows that the proposed method outperforms some of the state-of-the-art CNN-based methods on Dice, IoU, Acc, and modified Hausdorff distance (MHD) metrics; the improvements on metrics of Dice and MHD are statistically significant (p < 0.05). Furthermore, our HRU-Net transfer learning method shows fine generalization performance on 75 new images with varying degrees of plaque stenosis, and it may be used as an alternative for automatic noisy plaque segmentation in carotid ultrasound images clinically.
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The intima-media thickness (IMT) is an effective biomarker for atherosclerosis, which is commonly measured by ultrasound technique. However, the intima-media complex (IMC) segmentation for the IMT is challenging due to confused IMC boundaries and various noises. In this paper, we propose a flexible method CSM-Net for the joint segmentation of IMC and Lumen in carotid ultrasound images. Firstly, the cascaded dilated convolutions combined with the squeeze-excitation module are introduced for exploiting more contextual features on the highest-level layer of the encoder. Furthermore, a triple spatial attention module is utilized for emphasizing serviceable features on each decoder layer. Besides, a multi-scale weighted hybrid loss function is employed to resolve the class-imbalance issues. The experiments are conducted on a private dataset of 100 images for IMC and Lumen segmentation, as well as on two public datasets of 1600 images for IMC segmentation. For the private dataset, our method obtain the IMC Dice, Lumen Dice, Precision, Recall, and F1 score of 0.814 ± 0.061, 0.941 ± 0.024, 0.911 ± 0.044, 0.916 ± 0.039, and 0.913 ± 0.027, respectively. For the public datasets, we obtain the IMC Dice, Precision, Recall, and F1 score of 0.885 ± 0.067, 0.885 ± 0.070, 0.894 ± 0.089, and 0.885 ± 0.067, respectively. The results demonstrate that the proposed method precedes some cutting-edge methods, and the ablation experiments show the validity of each module. The proposed method may be useful for the IMC segmentation of carotid ultrasound images in the clinic. Our code is publicly available at https://github.com/yuanyc798/US-IMC-code.
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Espessura Intima-Media Carotídea , Processamento de Imagem Assistida por Computador , Processamento de Imagem Assistida por Computador/métodos , Algoritmos , Ultrassonografia/métodos , Artérias Carótidas/diagnóstico por imagemRESUMO
Mismatch negativity (MMN) has been consistently found deficit in schizophrenia, which was considered as a promising biomarker for assessing the impairments in pre-attentive auditory processing. However, the functional connectivity between brain regions based on MMN is not clear. This study provides an in-depth investigation in brain functional connectivity during MMN process among patients with first-episode schizophrenia (FESZ), chronic schizophrenia (CSZ) and healthy control (HC). Electroencephalography (EEG) data of 128 channels is recorded during frequency and duration MMN in 40 FESZ, 40 CSZ patients and 40 matched HC subjects. We reconstruct the cortical endogenous electrical activity from EEG recordings using exact low-resolution electromagnetic tomography and build functional brain networks based on source-level EEG data. Then, graph-theoretic features are extracted from the brain networks with the support vector machine (SVM) to classify FESZ, CSZ and HC groups, since the SVM has good generalization ability and robustness as a universally applicable nonlinear classifier. Furthermore, we introduce the graph neural network (GNN) model to directly learn for the network topology of brain network. Compared to HC, the damaged brain areas of CSZ are more extensive than FESZ, and the damaged area involved the auditory cortex. These results demonstrate the heterogeneity of the impacts of schizophrenia for different disease courses and the association between MMN and the auditory cortex. More importantly, the GNN classification results are significantly better than those of SVM, and hence the EEG-based GNN model of brain networks provides an effective method for discriminating among FESZ, CSZ and HC groups.