RESUMO
BACKGROUND: Preeclampsia (PE) represents a salient complication of late pregnancy. Long noncoding RNAs (LncRNAs) are critical biological regulators in PE. This study investigated lncRNA MIR193BHG expression and clinical significance in PE. METHODS: Serum samples were collected from 116 PE patients, including 62 cases of mild PE (mPE) and 54 cases of severe PE (sPE), with another 50 normal pregnant women as controls. LncRNA MIR193BHG expression in serum was detected by RT-qPCR. The correlation between MIR193BHG expression and clinical indicators was determined using Pearson analysis. The downstream microRNAs (miRNAs) and genes of MIR193BHG were predicted and verified through the database and dual-luciferase assay. Expressions of miR-345-3p and SASH1 in serum of PE patients were detected using RT-qPCR. RESULTS: LncRNA MIR193BHG was upregulated in the serum of PE patients, and MIR193BHG expression in mPE patients was lower than that in sPE patients. MIR193BHG expression was positively correlated with systolic and diastolic blood pressure, and urine protein. miR-345-3p was poorly expressed and SASH was highly expressed in serum of PE patients. There existed a binding relationship between MIR193BHG and miR-345-3p or between miR-345-3p and SASH. CONCLUSION: LncRNA MIR193BHG was upregulated in the serum of PE patients. Moreover, MIR193BHG might play a role in PE by competitively binding to SASH1 with miR-345-3p.