Evaluation standards regulate the generation and selection of novel ideas in creative behaviors: insights from individual differences in event-related potentials.

Evaluation is generally considered to occur after the generation of novel ideas to select truly creative ideas; however, evaluation may occur concurrently with the generation and regulate its efficiency. To test this hypothesis, 120 participants who held strict, moderate, or loose evaluation standards were grouped, and neural responses related to novel idea generation were compared retrospectively. The results showed that lower N400 amplitudes and greater LSP amplitudes were simultaneously elicited by objectively defined novel and usable options than by novel but unusable options among participants with moderate standards but not among participants with strict or loose standards. Evaluation standards influence the efficiency of novel idea generation; neither strict nor loose evaluation standards are conducive to fully resolving cognitive conflicts and generating novel ideas. Moreover, lower N400 amplitudes and greater LSP amplitudes were simultaneously elicited by the subjectively rated novel and usable option than by the novel but unusable option among participants with strict and moderate standards but not among participants with loose standards. Evaluation standards influence the selection among the generated ideas; participants in the strict and moderate groups made a wise choice based on the degree of conflict resolution, whereas participants in the loose group did not.

Divergent thinking benefits from functional antagonism of the left IFG and right TPJ: a transcranial direct current stimulation study.

Divergent thinking is assumed to benefit from releasing the constraint of existing knowledge (i.e. top-down control) and enriching free association (i.e. bottom-up processing). However, whether functional antagonism between top-down control-related and bottom-up processing-related brain structures is conducive to generating original ideas is largely unknown. This study was designed to investigate the effect of functional antagonism between the left inferior frontal gyrus and the right temporoparietal junction on divergent thinking performance. A within-subjects design was adopted for three experiments. A total of 114 participants performed divergent thinking tasks after receiving transcranial direct current stimulation over target regions. In particular, cathodal stimulation over the left inferior frontal gyrus and anodal stimulation over the right inferior frontal gyrus (Experiment 1), anodal stimulation over the right temporoparietal junction (Experiment 2), and both cathodal stimulation over the left inferior frontal gyrus and anodal stimulation over the right temporoparietal junction (Experiment 3) were manipulated. Compared with sham stimulation, the combination of hyperpolarization of the left inferior frontal gyrus and depolarization of the right temporoparietal junction comprehensively promoted the fluency, flexibility, and originality of divergent thinking without decreasing the rationality of generated ideas. Functional antagonism between the left inferior frontal gyrus (hyperpolarization) and right temporoparietal junction (depolarization) has a "1 + 1 > 2" superposition effect on divergent thinking.

A Combined Method of Seismic Monitoring and Transient Electromagnetic Detection for the Evaluation of Hydraulic Fracturing Effect in Coal Burst Prevention.

In order to mitigate the risk of roof-dominated coal burst in underground coal mining, horizontal long borehole staged hydraulic fracturing technology has been prevailingly employed to facilitate the weakening treatment of the hard roof in advance. Such weakening effect, however, can hardly be evaluated, which leads to a lack of a basis in which to design the schemes and parameters of hydraulic fracturing. In this study, a combined underground-ground integrated microseismic monitoring and transient electromagnetic detection method was utilized to carry out simultaneous evaluations of the seismic responses to each staged fracturing and the apparent resistivity changes before and after all finished fracturing. On this basis, the comparable and applicable fracturing effects on coal burst prevention were evaluated and validated by the distribution of microseismic events and their energy magnitude during the mining process. Results show that the observed mining-induced seismic events are consistent with the evaluation results obtained from the combined seismic-electromagnetic detection method. However, there is a limited reduction effect on resistivity near the fractured section that induces far-field seismic events. Mining-induced seismic events are concentrated primarily within specific areas, while microseismic events in the fractured area exhibit high frequency but low energy overall. This study validates the rationality of combined seismic-electromagnetic detection results and provides valuable insights for optimizing fracturing construction schemes as well as comprehensively evaluating outcomes associated with underground directional long borehole staged hydraulic fracturing.

Reconfiguration of response-set in task switching: Event-related potential evidence.

In task switching, an interaction between task and response is often observed, with response repetition (RR) benefits in task-repeat trials and RR costs in task-switch trials. The theoretical accounts of the RR effect remain controversial, and neuroscience evidence is scarce. The present study utilized the event-related potentials (ERPs) method to explore the neural mechanism underlying the RR effect by adopting a cued task-switching paradigm. The ERP results revealed the interaction between task and response in the P3b time window, with a response switch positivity under task-repetition conditions and an RR positivity under task-switching conditions. In addition, there were RR positivity in the N2 irrespective of task transition and in the late component (LC, 550-600 ms) that only under the task repetition condition. On the individual level, the RR benefit positively correlated with the RR positivity in the LC, while the RR costs negatively correlated with RR positivity in the N2/P3 component. These results suggest that both response reconfiguration and episodic-retrieval make contributions to the RR effects, which were also discussed in terms of predictive model for a domain-general inference and learning of perceptual categories.

Do after "not to do": Deinhibition in cognitive control.

In daily life, we often need to inhibit a certain behavior or thought; however, sometimes we need to remove inhibition (deinhibition). Numerous studies have examined inhibition control, but it is unclear how deinhibition functions. In Experiment 1, we adopted a modified stop-signal task in which participants were instructed to immediately stop the prepared response to a stimulus appended by an accidental signal. The results showed that when the preceding trial was a stop-signal trial and participants successfully inhibited the action to the stimulus, the reaction time (RT) for the repeated stimuli in the current trial was significantly longer than that of the switched stimuli, reflecting the cost of deinhibition. Deinhibition ability is correlated with inhibitory control and cognitive flexibility. In Experiment 2, we manipulated stimulus onset asynchrony (SOA) between presentation of the stimuli and the stopping signals to exclude the interference of the signal preparation effect on the deinhibition cost. These findings suggest that an individual's deinhibition ability, as a previously ignored subcomponent of cognitive control, may play an important role in human adaptive behavior.

More change in task repetition, less cost in task switching: Behavioral and event-related potential evidence.

Previous studies have shown that the probability of task switching can vary the level of cognitive control and modulate the size of switch costs. However, it is unclear whether switch costs would be affected by a task-repetition context formed by varying the degree of response (and task-relevant stimulus property) change within the task repetition sequences while the probability of task switching remains constant. In the present study, participants were presented with a string of digits (e.g., ②②②). Basing on stimulus color, they were required to indicate either the presented digit, or the number of presented digits. Before task switching, stimulus and response in consecutive task-repeat trials varied more or less frequently. Behavioral results showed that the frequent-change context elicited smaller switch costs than the rare-change context. Event-related potential (ERP) results indicated that: (1) the frequent-change context evoked greater fronto-central N2 amplitudes for both task-repeat and task-switch trials, implying that cognitive control increased due to the variation of stimulus and response associations; (2) for the task switch trials, smaller P300 amplitudes were evoked in the frequent-change context than the rare-change context, reflecting the promoted task-set reconfiguration. These findings suggest that, the more change in stimulus and response during task repetition, the higher the overall level of cognitive control and the higher efficiency of task-switching.

SNARC effect modulated by central executive control: revealed in a cue-based trisection task.

People respond to small numbers faster with the left hand and respond to large numbers faster with the right hand, a phenomenon known as the Spatial-Numerical Association of Response Codes (SNARC) effect. Whether the SNARC effect originates from culturally determined long-term experience or the task-set-influenced temporary associations among spaces, locations, and numerical magnitudes in working memory (WM) is still controversial. In the present study, we used a trisection paradigm in which numbers were divided into three categories (small: 1, 2; middle: 4, 5, 6; and large: 8, 9) to explore whether the central executive control can modulate the SNARC effect. Participants were serially presented with a cue and a target number. The cue denoted a task rule, which informed participants to compare the target number with either 3 or 7. The cue was either switched or repeated across trials. We found that the SNARC effects were observed in the cue-switching condition. In the cue-repeat condition, the SNARC effect disappeared. These findings suggest that the SNARC effect is modulated by set-shifting-related central executive control in WM, supporting the view that the SNARC effect is WM-dependent.

Learning and memory impairment of mice caused by gaseous formaldehyde.

In order to study the e of formaldehyde exposure on learning and memory ability of mice. We used Kun Ming (KM) mice to demonstrate the neurotoxic effects of FA, and Balb/c mice to explore the neurobiological mechanism. The Morris water maze (MWM) test showed that the exposure of gaseous formaldehyde could cause spatial learning and memory impairment in mice. H & E staining showed that in the 3.0 mg/m3 formaldehyde exposed group, the arrangement of pyramidal cells in CA1 area of mouse hippocampus was loose and disordered, the cell morphology was swollen and deformed, and the apical dendrites were shortened or even disappeared. Biochemical indicators revealed high doses of FA exposure could cause oxidative damage in brain. Compared with the control group, there were significant differences in the levels of ROS, MDA, GSH and 8-OHDG in the 3.0 mg/m3 group (P < 0.01), also the monoamine neurotransmitters content and the content of TNF-α, IL-1ß and Caspase-3 (P < 0.01). Furthermore, the concentrations of cAMP, cGMP, NO and the activity of NOS in the cerebral cortex, hippocampus and brain stem after high doses of FA exposure were significantly different from those in the control group, indicating that FA exposure could interfere with the transduction of NO/cGMP signaling pathway. The results showed that FA could induce cognitive deficits and this extended investigation found that the toxicity of FA to the mouse nervous system is related to the NO/cGMP and cAMP signaling pathways.

Low concentrations of FA exhibits the Hormesis effect by affecting cell division and the Warburg effect.

Formaldehyde (FA), a ubiquitous indoor environmental pollutant, has been classified as a carcinogen. There are many studies showed that low levels of FA could promote cell proliferation, however, little is known about the signal pathways. To determine the potential molecular mechanisms, human chronic myeloid leukemia cells (K562 cells) and human bronchial epithelial cells (16HBE cells) were exposed to different concentrations of FA. The data showed that FA at 0-125 µM or 0-60 µM promoted the proliferation of K562 cells or 16HBE cells respectively, indicating that FA did have the Hormesis effect. FA at 75 µM (K562 cells) and 40 µM (16HBE cells) significantly promoted cell proliferation, increased intracellular reactive oxygen species (ROS) levels, and decreased glutathione (GSH) content. At the same time, FA treatment induced a marked increase in the key molecules of cell division like CyclinD-cdk4 and E2F1. In addition, pyruvate kinase isozyme M2 (PKM2), glucose, glucose transporter 1 (GLUT1), lactic acid and lactate dehydrogenase A (LDHA) content in the Warburg effect were increased. Administering Vitamin E (VE), significantly disrupted cell division and disturbed the Warburg effect, effectively indicating the decrease of cell activity. Conclusively, these findings suggested that low concentrations of FA could promote cell proliferation by accelerating cell division process or enhancing the Warburg effect to embody the Hormesis effect.

Functional imaging of brain responses to different outcomes of hypothesis testing: revealed in a category induction task.

Functional magnetic resonance imaging (fMRI) was used to examine differences in brain activation that occur when a person receives the different outcomes of hypothesis testing (HT). Participants were provided with a series of images of batteries and were asked to learn a rule governing what kinds of batteries were charged. Within each trial, the first two charged batteries were sequentially displayed, and participants would generate a preliminary hypothesis based on the perceptual comparison. Next, a third battery that served to strengthen, reject, or was irrelevant to the preliminary hypothesis was displayed. The fMRI results revealed that (1) no significant differences in brain activation were found between the 2 hypothesis-maintain conditions (i.e., strengthen and irrelevant conditions); and (2) compared with the hypothesis-maintain conditions, the hypothesis-reject condition activated the left medial frontal cortex, bilateral putamen, left parietal cortex, and right cerebellum. These findings are discussed in terms of the neural correlates of the subcomponents of HT and working memory manipulation.

Electrophysiological correlates of the effect of set size on object switching in working memory.

Previous studies have revealed the effect of set size (the number of activated items) on object switching in working memory, but the underlying neural mechanism remains unclear. In this study, participants were asked to first remember two (small size) or three (large size) two-digit numbers and the corresponding geometrical figures as different references for numerical comparison and then compare a series of numbers (10-99) to the reference numbers cued by different geometrical figures. The cue repeated or switched across trials. Behavioral results revealed that the switch cost was greater in the large-size condition than in the small-size condition. Event-related potential results showed that in the N2 component, an interaction was observed between set size and transition, with a significant transition effect (switch minus repeat) in the large-size condition and a non-significant transition effect in the small-size condition. The same interaction was observed in the P3 component, with a larger amplitude difference (switch minus repeat) in the large-size condition than in the small-size condition. These results suggested that when set size is increased, the effort to inhibit the irrelevant items increases, resulting in large cost of object switching in working memory.

Consequences of scarcity: the impact of perceived scarcity on executive functioning and its neural basis.

Introduction: Previous studies have found a causal relationship between scarcity and the adverse impact it has on executive functioning. However, few studies have directly examined perceived scarcity, and cognitive flexibility (the third component of executive functions) has rarely been included. Methods: Using a 2 (group: scarcity group vs. control group) × 2 (trial type: repeat trial vs. switch trial) mixed design, this study directly explored perceived scarcity's impact on cognitive flexibility and revealed its neural basis in the switching tasks. Seventy college students participated in this study through open recruitment in China. A priming task was used to induce perceived scarcity, thus exploring the impact of perceived scarcity on participants' performance in switching tasks and enabling the analysis of the neural activity of the brain, combined with electroencephalograph (EEG) technology. Results: In terms of behavioral outcomes, perceived scarcity led to poorer performance and a greater switching cost of reaction time in the switching tasks. Regarding neural activity, perceived scarcity led to an increase in the amplitude of P3 differential wave (repeat trials minus switch trials) in the parietal cortex during the target-locked epochs in the switching tasks. Discussion: Perceived scarcity can lead to changes in the neural activity of the brain regions related to executive functioning, resulting in a temporary decrease in cognitive flexibility. It may lead to individuals unable to adapt well to the changing environment, unable to quickly devote themselves to new tasks, and reduce work and learning efficiency in daily life.

Cognitive control in creative discovery: The gap between ideal and reality.

Creative discovery involves discovering the additional values of existing things in the environment by identifying the novel associations between seemingly unrelated things; the judgment made in this process is expected to be accurate but not entirely correct. From the perspective of cognitive processing, what is the difference between the ideal and real states of creative discovery? This is largely unknown. In this study, a daily life scenario was presented, and a great number of seemingly unrelated tools were presented for participants to discover valuable tools. Electrophysiological activity was recorded when participants identified tools, and we then retrospectively analyzed the differences between responses. Compared with usual tools, unusual tools evoked greater N2, N400 and late sustained potential (LSP) amplitudes, which was likely associated with the monitoring and resolution of cognitive conflicts. Moreover, unusual tools evoked smaller N400 and greater LSP amplitudes when correctly identified as usable than when identified as unusable; this result suggested that creative discovery in the ideal state should depend on the cognitive control involved in resolving conflicts. However, in the comparison between subjectively rated usable and unusable tools, smaller N400 and greater LSP amplitudes were observed only when unusual tools could be identified by expanding the application scope but not by releasing functional fixedness; this outcome suggested that creative discovery in the real state was not always influenced by the cognitive control involved in resolving conflicts. The difference in cognitive control that should be exerted and that was actually exerted to identify novel associations was discussed.

When and why will creative discovery succeed or fail? The role of reactive control in resolving conflicts.

The process of creative discovery refers to discovering additional values of existing objects by identifying novel associations between seemingly unrelated things; however, this process is not always successful. To reveal the dynamic process of creative discovery, particularly when and why people made right or wrong judgments, the daily life scenario was described, and a possible tool was presented for judging whether it is usable to solve problems. Electrophysiological activity was recorded when people identified novel tools and then retrospectively analyzed the differences among three responses: correctly identified novel and usable (C-NU) options, falsely identified novel and usable (F-NU) options, and correctly identified novel but unusable (C-NUU) options. The results showed that, compared with ordinary tools, novel tools evoked greater N2, N400 and LSP amplitudes; the differences in these components were likely associated with the monitoring and resolution of cognitive conflicts in the process of discovering novel associations. Regarding novel tools, smaller N400 and greater LSP amplitudes were evoked by the C-NU option than by the F-NU option, and no differences in these components were found between the F-NU and C-NUU options. The findings revealed that the success or failure of discovering novel associations depended on reactive control in resolving conflicts. Only when sufficient cognitive effort is used to resolve a conflict to a great degree can the appropriately novel association be successfully discovered; otherwise, the novel and appropriate association is lost.

Stronger spatial bias induced more by numbers in mind than numbers in eye: Evidence from event-related potentials.

The relationship between number and space is an important issue in numerical cognition. The spatial-numerical association of response codes (SNARC) effect is a classic example of the association between numbers and spaces. It refers to the phenomenon whereby left-handed responses occur faster to small number and right-handed responses occur faster to large number. The current study explored the shared and distinct neural correlates of the SNARC effect considering numbers in eye and numbers in mind, by using event-related potentials (ERPs) technology. In each trial of the task, participants were asked to press freely one of two keys as a response to a number presented visually (numbers in eye) or via imagination (numbers in mind). The behavioral results indicated that the free-choice key presses were affected by the magnitudes of the numbers either in eye or in mind. Electrophysiological results observed that the SNARC effect appeared only in the 110-140 ms time window for numbers in eye. In contrast, for numbers in mind, the SNARC effect appeared during a longer time window (110-330 ms). These results suggest that both, numbers in eye and numbers in mind, can induce spatial bias at the early stimulus-representation stage, but the time duration of the spatial bias is longer for numbers in mind than numbers in eye. This may reflect a closer connection between numbers in mind and mental number line.

An ERP study on the processing of common fractions.

The aim of this study was to examine how adults processed common fractions with common numerators under two distinct conditions. Whereas participants were presented with only common fractions in a "simple" condition, a "complex" condition involved the random presentation of common fractions as well as decimal fractions. In both conditions, participants were required to assess whether various "target" fractions were larger than or smaller than a "standard" common fraction (1/5). Behavioral results indicated that under both conditions, participants mentally processed the fractions componentially in terms of their constituent parts rather than holistically in terms of the numerical value of the fraction as a whole. The data provided by the event-related potentials (ERPs) demonstrated electrophysiological correlates of the componential processing of common fractions in the simple condition, as reflected in the latency and amplitude of P3. However, in contrast to what the behavioral data showed, there was no strong electrophysiological evidence to indicate that common fractions were accessed componentially in the complex condition. In addition, the complex condition was linked to longer latency and more negative amplitude of N2 over the frontal scalp than the simple condition, which could be attributed to the fact that the comparison of fractions in the complex condition involved task switching and thus was more taxing on cognitive control than the simple condition.

Cognitive Neural Mechanism of Backward Inhibition and Deinhibition: A Review.

Task switching is one of the typical paradigms to study cognitive control. When switching back to a recently inhibited task (e.g., "A" in an ABA sequence), the performance is often worse compared to a task without N-2 task repetitions (e.g., CBA). This difference is called the backward inhibitory effect (BI effect), which reflects the process of overcoming residual inhibition from a recently performed task (i.e., deinhibition). The neural mechanism of backward inhibition and deinhibition has received a lot of attention in the past decade. Multiple brain regions, including the frontal lobe, parietal, basal ganglia, and cerebellum, are activated during deinhibition. The event-related potentials (ERP) studies have shown that deinhibition process is reflected in the P1/N1 and P3 components, which might be related to early attention control, context updating, and response selection, respectively. Future research can use a variety of new paradigms to separate the neural mechanisms of BI and deinhibition.

Reconfiguration of response rule is more difficult than that of task goal: Behavior and electrophysiological evidence.

Previous studies have investigated the neural mechanisms underlying cognitive control by using the task-switching paradigm, but differentiation from response rule switching (RR-switch) remains poorly explored. In this study, a partial voluntary task-switching (VTS) paradigm was used to explore the electrophysiological differences between task switching (T-switch) and RR-switching. Participants were sequentially presented with Arabic numerals colored red or green. If the color in the current trial was the same as that in the previous trial, the participants had to perform the same task following the same response rule. Otherwise, they had to voluntarily switch tasks (e.g., from parity task to magnitude task) or switch response rules (e.g., from "pressing F for odd and J for even number" to "pressing J for odd and F for even number"). The behavioral results indicated that RR-switch was infrequently selected, and the performance was less efficient than that of the T-switch. Event-related potential results showed that both T- and RR-switches elicited a larger switch-positivity in the P2 and P3 time windows than that in the repeat condition. Switch-positivity was larger for RR-switch than for T-switch over the frontal sites, suggesting that more attention and cognitive resources were required to update information for the RR-switch than for the T-switch. These findings suggest that in the VTS, the hierarchical relationship between task goals and response rules is relatively loose, resulting in the neural disassociation of task reconfiguration and response change.

The role of cognitive control in the SNARC effect: A review.

The spatial-numerical association of response codes (SNARC) effect, in which people respond to small numbers faster with the left hand and to large numbers faster with the right hand, is a popular topic in cognitive psychology. Some well-known theoretical accounts explaining this effect include the mental number line model, polarity correspondence principle, dual-route model, and working memory account. However, these fail to explain the finding that the size of the SNARC effect is modulated by cognitive control. Here, we propose a new account-a cognitive control-based view of the SNARC effect. This view argues that the SNARC effect is fundamentally determined by cognitive control in resolving conflicts during stimulus-response mapping. Several subcomponents of cognitive control, such as working memory, mental or task set shifting, inhibition control, and conflict adaptation, can easily modulate the SNARC effect. The cognitive control-based view can account for the flexible SNARC effect observed in diverse task situations while providing new insight into its mechanism.

Cognitive control is modulated by hierarchical complexity of task switching: An event-related potential study.

The study aimed to explore the effect of hierarchical complexity on task switching. The participants (n = 36) were asked to perform a magnitude or parity judgement on digits (1-9) in the hierarchical simple or complex block. In the simple block, participants made a numerical judgement on the presented digit (1-9) in each trial, whereas in the complex block, they had to first identify whether the digit in the current trial belonged to a predefined category (e.g., whether it was an even number), then perform a numerical judgement or not respond. The behavioural results revealed a significant interaction between hierarchical complexity and transition type (repeat vs. switch), with greater switch cost in the complex than in the simple block. Event-related potentials (ERPs) locked in the cue stage did not reveal this interaction, whereas the ERPs locked in the target stage revealed this interaction during the N2 and P3 time windows, with a larger switch negativity (switch minus repeat) in the complex than in the simple block. These findings demonstrate that an increase in hierarchical complexity triggers increased reactive control in the inhibition of the old task-set and reconfiguration of the new task-set during task switching.