Detalhe da pesquisa
1.
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Nature
; 586(7831): 735-740, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32879487
2.
Nanosensor-based monitoring of autophagy-associated lysosomal acidification in vivo.
Nat Chem Biol
; 19(12): 1448-1457, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37322156
3.
HuM195 and its single-chain variable fragment increase Aß phagocytosis in microglia via elimination of CD33 inhibitory signaling.
Mol Psychiatry
; 2024 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38383769
4.
Cu(II)-Catalyzed Enantioselective Aza-Friedel-Crafts Reaction of 1-Naphthols and Electron-Rich Phenols with Isatin-Derived Ketimines.
Chemistry
; 30(27): e202304118, 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38433408
5.
γ-Secretase fanning the fire of innate immunity.
Biochem Soc Trans
; 51(4): 1597-1610, 2023 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37449907
6.
Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aß production under hypoxia and cerebral hypoperfusion.
Mol Psychiatry
; 27(10): 4264-4273, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35764706
7.
New Binaphthyl-Proline-Based Chiral Ligands Bearing Imidazoline Groups: Design, Synthesis, and Their Application in Enantioselective Conjugate Addition of 4-Hydroxycoumarin and Related Nucleophiles to ß,γ-Unsaturated α-Ketoesters.
J Org Chem
; 88(21): 14928-14944, 2023 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37874252
8.
Enantioselective Friedel-Crafts Alkylation of Indoles with ß,γ-Unsaturated α-Ketoesters Catalyzed by New Copper(I) Catalysts.
J Org Chem
; 88(5): 3046-3053, 2023 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36791262
9.
Copper(II)-Catalyzed Enantioselective Aza-Friedel-Crafts Reaction of Indoles with Isatin-Derived N-Boc-Ketimines.
J Org Chem
; 88(20): 14345-14350, 2023 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37791977
10.
Binaphthyl-Proline Hybrid Chiral Ligands: Modular Design, Synthesis, and Enantioswitching in Cu(II)-Catalyzed Enantioselective Henry Reactions.
J Org Chem
; 88(12): 7651-7659, 2023 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36106472
11.
Enantioselective Michael addition of malonates to ß,γ-unsaturated α-ketoesters catalysed by Cu(II) complexes bearing binaphthyl-proline hybrid ligands.
Org Biomol Chem
; 21(8): 1764-1770, 2023 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36723244
12.
γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase.
Semin Cell Dev Biol
; 105: 43-53, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32249070
13.
miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database.
Nucleic Acids Res
; 48(D1): D148-D154, 2020 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31647101
14.
Split-face comparison of the efficacy of picosecond 532 nm Nd:YAG laser and Q-switched 755 nm Alexandrite laser for treatment of freckles.
J Cosmet Laser Ther
; 24(1-5): 22-27, 2022 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35400288
15.
GSAP modulates γ-secretase specificity by inducing conformational change in PS1.
Proc Natl Acad Sci U S A
; 116(13): 6385-6390, 2019 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30850537
16.
Binaphthyl-prolinol chiral ligands: design and their application in enantioselective arylation of aromatic aldehydes.
Org Biomol Chem
; 19(16): 3644-3655, 2021 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33908558
17.
γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.
Langmuir
; 36(23): 6569-6579, 2020 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32432881
18.
Dolutegravir derivative inhibits proliferation and induces apoptosis of non-small cell lung cancer cells via calcium signaling pathway.
Pharmacol Res
; 161: 105129, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32783976
19.
Binaphthyl-based chiral ligands: design, synthesis and evaluation of their performance in enantioselective addition of diethylzinc to aromatic aldehydes.
Org Biomol Chem
; 18(47): 9712-9725, 2020 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33237100
20.
Design, synthesis and antitumor activity of icotinib derivatives.
Bioorg Chem
; 105: 104421, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33181408